897359-58-9

Upstream product

• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 897359-60-3 6-(3,4-dimethoxyphenyl)-3-nitropyridine-2-carbonitrile 
• 93683-65-9 6-chloro-3-nitropicolinonitrile 

Downstream Products

• 897359-55-6 6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidin-4(3H)-one 
• 897359-64-7 2-methyl-6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidin-4(3H)-one 
• 897359-67-0 6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidin-2(1H)-4(3H)-dione 

Relevant academic research and scientific papers

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase

Previously, we reported the discovery of 3,6-disubstituted isothiazolo[4,3-b]pyridines as potent and selective cyclin G-associated kinase (GAK) inhibitors with promising antiviral activity. In this manuscript, the structure-activity relationship study was expanded to synthesis of isothiazolo[4,3-b]pyridines with modifications of the pyridine moiety. This effort led to the discovery of an isothiazolo[4,3-b]pyridine derivative with a 3,4-dimethoxyphenyl residue at position 5 that displayed low nanomolar GAK binding affinity and antiviral activity against dengue virus.

PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C.

Specifically substituted pyrido(3,2-d)pyrimidine derivatives having the structural formula (I) are useful for the treatment of hepatitis C.