897383-73-2

Upstream product

• 179688-70-1 N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine 
• 19815-16-8 4-chloro-6-nitro-quinazoline 
• 6943-17-5 6-nitroquinazolone 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 179688-74-5 N⁴-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)quinazoline-4,6-diamine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 

Downstream Products

• 897025-07-9 (2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide 

Relevant academic research and scientific papers

Discovery of a novel Her-1/Her-2 dual tyrosine kinase inhibitor for the treatment of Her-1 selective inhibitor-resistant non-small cell lung cancer

A novel series of (S)-1-acryloyl-N-[4-(arylamino)-7-(alkoxy)quinazolin-6- yl]pyrrolidine-2-carboxamides were synthesized and evaluated as Her-1/Her-2 dual inhibitors. In contrast to the Her-1 selective inhibitors, our novel compounds are irreversible inhi