897386-72-0Relevant academic research and scientific papers
Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures
Shimizu, Kazuki,Kawase, Akira,Haneishi, Tsuyoshi,Kato, Yasuharu,Kinoshita, Kazutomo,Ohmori, Masayuki,Furuta, Yoshiyuki,Emura, Takashi,Kato, Nobuaki,Mitsui, Tetsuya,Yamaguchi, Koji,Morita, Keiichi,Sekiguchi, Nobuo,Yamamoto, Tessai,Matsushita, Tomochika,Shimaoka, Shin,Sugita, Atsuko,Morikawa, Kazumi
, p. 3323 - 3329 (2008/12/23)
Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit grea
Vitamin d derivatives
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Page/Page column 52-53, (2010/02/05)
The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): wherein X represents an oxygen atom or a sulfur atom; m represents a number of 1 to 3; R1 and R2 each represent a hydrogen atom or an alkyl group; R4 and R5 each represent a hydrogen atom or a hydroxyl group, etc.; R3 represents —YR8, etc.; R6 represents a hydrogen atom, etc.; and R7 represents a hydrogen atom, etc.
