89753-67-3Relevant articles and documents
SYNTHESIS OF 2-(HETEROCYCLYLTHIOMETHYL)PENEMS
Alpegiani, Marco,Bedeschi, Angelo,Franceschi, Giovanni,Giudici, Franco,Nannini, Giuliano,Perrone, Ettore
, p. 319 - 324 (2007/10/02)
The synthesis of representatives of an important class of penem antibiotics is described, exploiting a new procedure for preparing phosphoranes from base-sensitive chlorides and a purpose-tailored carboxyl protective group.Double bond migration out of the ring to give 2-(heterocyclylthiomethylene)penams was observed even in pH 7.4 phosphate buffer.