89778-27-8 Usage
Uses
Used in Pharmaceutical Industry:
Toremifene citrate is used as an antiestrogen and antineoplastic agent for its nonsteroidal antiestrogen properties, structurally similar to tamoxifen.
Used in Research Applications:
In cell-based ELISA, Toremifene citrate salt is utilized as a positive control to detect its antiviral activity against Ebola virus (EBOV).
Used in Oncology:
Toremifene citrate salt has been employed to treat MCF7 and T47D breast cancer cell lines, showcasing its potential in combating cancer.
Originator
Fareston,Orion Corporation,Finland
Biochem/physiol Actions
Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy?.
Check Digit Verification of cas no
The CAS Registry Mumber 89778-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,7,7 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 89778-27:
(7*8)+(6*9)+(5*7)+(4*7)+(3*8)+(2*2)+(1*7)=208
208 % 10 = 8
So 89778-27-8 is a valid CAS Registry Number.
InChI:InChI=1/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
89778-27-8Relevant articles and documents
POLYMORPHIC FORM OF TOREMIFENE CITRATE AND PROCESS FOR ITS PREPARATION
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Page/Page column 14, (2011/02/24)
The present invention provides a polymorphic form of toremifene citrate and processes for its preparation. It also relates to an improved process for the preparation of the Z isomer of the toremifene base, free of E isomer, and its pharmaceutically acceptable salts.
