89778-41-6

Usage

Uses

Used in Pharmaceutical Industry:
Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)is used as a selective estrogen receptor modulator (SERM) for the treatment of dyspareunia, a condition characterized by pain during sexual intercourse. As a SERM, it acts similarly to estrogen and can help alleviate symptoms associated with this condition.
Additionally, it may have potential applications in other areas where estrogen-like effects are beneficial, such as in the treatment of osteoporosis or certain types of breast cancer. However, further research and clinical trials would be necessary to explore these potential uses.

Upstream product

• 495-40-9 propiophenone 
• 1137-42-4 4-Hydroxybenzophenone 
• 936-59-4 3-chloropropiophenone 

Downstream Products

• 128607-22-7 ospemifene 
• 341527-08-0 (Z)-[4-(4-Chloro-1,2-diphenylbut-1-enyl]phenoxy)acetic Acid Ethyl Ester 
• 341526-24-7 2-(2-{2-[4-((Z)-4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethoxy)tetrahydropyran 

Relevant academic research and scientific papers

Method for Producing Phenoxyethanol Derivative

Provided is a method for producing a phenoxyethanol derivative. This method for producing a compound represented by formula (II) is characterized in that a compound represented by formula (I) (in the formula, R1 is a substituted or unsubstituted alkyl) is reduced in the presence of lithium borohydride.

METHOD FOR PRODUCING TRIPHENYLBUTENE DERIVATIVE

We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV): wherein R1 is hydrogen or substituted or unsubstituted alkyl, characterized by reacting a compound represented by Formula (V): with a compound represented by Formula (VI): wherein R1 has the same meaning as defined above, in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and/or a substituted or unsubstituted phenol.

METHOD FOR THE PREPARATION OF THERAPEUTICALLY VALUABLE TRIPHENYLBUTENE DERIVATIVES

The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.