89778-41-6

Basic information

• Product Name: Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)-
• Synonyms: Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z);Phenol, 4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]-;(Z)-4-Chloro-1,2-diphenyl-1-[4-hydroxyphenyl]-butene;Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)-
• CAS NO: 89778-41-6
• Molecular Formula: C22H19ClO
• Molecular Weight: 334.845
• Mol File: 89778-41-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)-(89778-41-6)
• EPA Substance Registry System: Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)-(89778-41-6)

Safety Data

• Hazardous Substances Data: 89778-41-6(Hazardous Substances Data)

Usage

Description

Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)is a chemical compound derived from 4-Hydroxybenzophenone (H829305), which is a metabolite of benzophenone. It is also the Z isomer of (E)-4-(4-Chloro-1,2-diphenylbut-I-en-I-yl)phenol (O703015), a derivative of Ospemifene (O703000) impurity. Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)is a selective estrogen receptor modulator (SERM) and exhibits estrogen-like effects in certain tissues.

Uses

Used in Pharmaceutical Industry:
Phenol, 4-(4-chloro-1,2-diphenyl-1-butenyl)-, (Z)is used as a selective estrogen receptor modulator (SERM) for the treatment of dyspareunia, a condition characterized by pain during sexual intercourse. As a SERM, it acts similarly to estrogen and can help alleviate symptoms associated with this condition.
Additionally, it may have potential applications in other areas where estrogen-like effects are beneficial, such as in the treatment of osteoporosis or certain types of breast cancer. However, further research and clinical trials would be necessary to explore these potential uses.

Upstream product

• 936-59-4 3-chloropropiophenone 
• 1137-42-4 4-Hydroxybenzophenone 
• 495-40-9 propiophenone 

Downstream Products

• 128607-22-7 ospemifene 
• 341527-08-0 (Z)-[4-(4-Chloro-1,2-diphenylbut-1-enyl]phenoxy)acetic Acid Ethyl Ester 
• 341526-24-7 2-(2-{2-[4-((Z)-4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethoxy)tetrahydropyran 

Relevant articles and documents

Method for Producing Phenoxyethanol Derivative

Provided is a method for producing a phenoxyethanol derivative. This method for producing a compound represented by formula (II) is characterized in that a compound represented by formula (I) (in the formula, R1 is a substituted or unsubstituted alkyl) is reduced in the presence of lithium borohydride.

METHOD FOR THE PREPARATION OF THERAPEUTICALLY VALUABLE TRIPHENYLBUTENE DERIVATIVES

The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.