89782-10-5

Basic information

• Product Name: 6-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carboxylic acid
• CAS NO: 89782-10-5
• Molecular Formula: C₁₄H₁₂N₂O₂
• Molecular Weight: 240.2573
• Mol File: 89782-10-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 481.1°C at 760 mmHg
• Flash Point: 244.7°C
• Density: 1.31g/cm³
• Vapor Pressure: 4.59E-10mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 6-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carboxylic acid(89782-10-5)
• EPA Substance Registry System: 6-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carboxylic acid(89782-10-5)

Safety Data

• Hazardous Substances Data: 89782-10-5(Hazardous Substances Data)

Downstream Products

• 135922-33-7 6-Imidazol-1-yl-5,6,7,8-tetrahydro-naphthalene-1-carboxylic acid 

Relevant articles and documents

N-Imidazolyl derivatives of the naphthalene and chroman rings as thromboxane A2 synthase inhibitors

A series of N-imidazol-1-yl derivatives of 1,2-dihydronaphthalene, 1,2,3,4-tetrahydronaphthalene, 2H-1-benzopyran and some related compounds were synthesized and tested as inhibitors of thromboxane A2 synthase in ex vivo experiments with orally treated rats.Some compounds showed good activity which was confirmed in experiments in vitro in rabbit whole blood.Some structural requirements for significant TxA2 synthase inhibitory activity are discussed.The selected 5,6-dihydro-7-(1H-imidazol-1-yl)-2-naphthalene-carboxylic acid (compound 7) was conformationally analysed using the Sybyl molecular model system in comparison with dazoxiben.Compound 7 was further pharmacologically investigated and on the basis of its interesting activities in vitro, ex vivo and in vivo and its low toxicity was selected for clinical investigation.