89790-19-2

Upstream product

• 112052-43-4 methyl 8-hydroxyoctanoate tosylate 
• 89790-31-8 8-(4-Cyanomethyl-phenoxy)-octanoic acid methyl ester 
• 14191-95-8 4-cyanomethylphenol 
• 20257-95-8 8-hydroxyoctanoic acid methyl ester 
• 89790-20-5 8-(4-Carbamoylmethyl-phenoxy)-octanoic acid methyl ester 

Downstream Products

• 89790-21-6 8-(4-Carbamoylmethyl-phenoxy)-octanoic acid amide 

Relevant academic research and scientific papers

Design of Inhibitors from the Three-Dimensional Structure of Alcohol Dehydrogenase. Chemical Synthesis and Enzymatic Properties

Inhibitors of liver alcohol dehydrogenase were designed from the three-dimensional structure of the enzyme.The ligand to the catalytic zinc ion is an amide group or, better, a formamide group.With the latter function, a hydrogen bond between the NH group and the hydroxyl group of Ser-48 may be formed.The hydrophobic substrate binding site brings structural restraints. α-ω bifunctional molecules show good inhibitory properties possibly due to the interactions with polar residues at the entrance of the substrate binding site.