897942-80-2

Basic information

• Product Name: 6-Bromo-2-pyridinecarboxaldehyde-1-oxide
• Synonyms: 6-Bromo-2-pyridinecarboxaldehyde-1-oxide
• CAS NO: 897942-80-2
• Molecular Formula: C₆H₄BrNO₂
• Molecular Weight: 202.01
• Mol File: 897942-80-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Bromo-2-pyridinecarboxaldehyde-1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-pyridinecarboxaldehyde-1-oxide(897942-80-2)
• EPA Substance Registry System: 6-Bromo-2-pyridinecarboxaldehyde-1-oxide(897942-80-2)

Safety Data

• Hazardous Substances Data: 897942-80-2(Hazardous Substances Data)

Upstream product

• 897943-05-4 (6-bromo-1-oxypyridin-2-yl)methanol 
• 33674-96-3 2-bromo-6-(hydroxymethyl)pyridine 
• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 
• 626-05-1 2,6-Dibromopyridine 

Relevant articles and documents

Bis(oxazoline) lewis acid catalyzed aldol reactions of pyridine N-oxide aldehydes-synthesis of optically active 2-(1-hydroxyalkyl)pyridine derivatives: Development, scope, and total synthesis of an indolizine alkaloid

A new. short, and simplified procedure for the synthesis of optically active pyridine derivatives from prochiral pyridine-N-oxides is presented. The catalytic and asymmetric Mukaiyama aldol reaction between ketene silyl acetals and l-oxypyridine-2-carhaldehyde derivatives catalyzed by chiral copper(ii)-bis(oxazoline) complexes gave optically active 2-(hydroxyalkyl)-and 2-(anti-1.2-dihydroxyalkyl)pyridine derivatives in good yields and diastereoselectivities, and in excellent enantioselectivities - up to 99% enantiomeric excess. As a synthetic application of the developed method, a full account for the asymmetric total synthesis of a nonnatural indolizine alkaloid is provided.