897957-06-1

Basic information

• Product Name: 6-Bromo-1-methylindolin-2-one
• Synonyms: 6-Bromo-1-methylindolin-2-one
• CAS NO: 897957-06-1
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.06992
• Mol File: 897957-06-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 402.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.589±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.82±0.20(Predicted)
• CAS DataBase Reference: 6-Bromo-1-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1-methylindolin-2-one(897957-06-1)
• EPA Substance Registry System: 6-Bromo-1-methylindolin-2-one(897957-06-1)

Safety Data

• Hazardous Substances Data: 897957-06-1(Hazardous Substances Data)

Usage

General Description

6-Bromo-1-methylindolin-2-one is a chemical compound with the molecular formula C9H8BrNO. It is a derivative of indolin-2-one, a heterocyclic compound found in plants and some pharmaceuticals. The bromine atom at position 6 of the indolin-2-one ring gives the compound its characteristic properties. It is used in organic synthesis as a building block for the production of various pharmaceuticals and organic compounds. 6-Bromo-1-methylindolin-2-one has potential applications in the development of new drugs and biologically active molecules, as well as in the study of organic chemistry and chemical reactions. Overall, 6-Bromo-1-methylindolin-2-one is a valuable chemical compound with important applications in the fields of pharmaceuticals and organic synthesis.

Upstream product

• 6326-79-0 6-bromoisatin 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 
• 77-78-1 dimethyl sulfate 
• 667463-64-1 6-bromo-N-methylisatin 

Downstream Products

• 1254319-34-0 (S)-tert-butyl 4-(1-amino-3-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate 
• 1258324-50-3 (S)-tert-butyl 2-((S)-1-amino-3-(4-(1-methyl-2-oxoindolin-6-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)piperidine-1-carboxylate 
• 1428666-17-4 1-methyl-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1,3-dihydroindol-2-one 
• 1596355-37-1 ethyl (3S)-6-bromo-3-[(3S)-2,5-dioxo-1-phenylpyrrolidin-3-yl]-1-methyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylate 
• 1579957-40-6 (3R,3'R,5'R)-6-bromo-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione 

Relevant articles and documents

3-Carboxamide oxindoles as 1,3-C,N-bisnucleophiles for the highly diastereoselective synthesis of CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atom

A simple and efficient strategy has been established for the synthesis of δ-lactam fused oxindoles via the Michael/N-hemiketalization cascade reaction of 3-carboxamide oxindoles and α,β-unsaturated trifluoromethyl ketones. A wide range of structurally novel CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atoms were obtained in moderate to good yields with excellent diastereoselectivities under mild conditions. This work represents the first example of a systematic study of 3-carboxamide oxindoles as 1,3-C,N bisnucleophiles.

PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles

In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 ? in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal-free protocol for a wide range of biologically important 3-hydroxy-3-(2-oxo-alkyl)-2-oxindoles.