897958-99-5

Usage

Uses

Used in Organic Synthesis:
1H-Isoindol-1-one, 2,3-dihydro-5-iodois used as a building block in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the creation of new molecules with potential applications in various industries.
Used in Pharmaceutical Research:
1H-Isoindol-1-one, 2,3-dihydro-5-iodois used as a key intermediate in the development of new drugs. Its iodinated nature allows for the exploration of its potential in medicinal chemistry, where it can be incorporated into the design of novel therapeutic agents.
Used in Medicinal Chemistry:
1H-Isoindol-1-one, 2,3-dihydro-5-iodois used as a starting material for the synthesis of biologically active molecules. Its presence in the molecular structure can influence the pharmacological properties of the resulting compounds, making it a promising candidate for the development of new drugs.
Used in Chemical Reactions as a Reagent:
1H-Isoindol-1-one, 2,3-dihydro-5-iodois used as a reagent in various chemical reactions in the laboratory. Its unique properties can facilitate the synthesis of complex molecules and contribute to the advancement of chemical research.

Upstream product

• 103440-53-5 4-iodo-2-methyl-benzoic acid methyl ester 
• 341011-40-3 methyl 2-(bromomethyl)-4-iodobenzoate 

Downstream Products

• 1313397-67-9 2-ethyl-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one 
• 1567836-85-4 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide 

Relevant academic research and scientific papers

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure-activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed 2-thioxoimidazolidin-4-one/thiophene core. The ability of the resulting compounds to inhibit the lytic activity of both isolated perforin protein and perforin delivered in situ by natural killer cells was determined. A number of compounds showed excellent activity at concentrations that were nontoxic to the killer cells, and several were a significant improvement on previous classes of inhibitors, being substantially more potent and soluble. Representative examples showed rapid and reversible binding to immobilized mouse perforin at low concentrations (≤2.5 μM) by surface plasmon resonance and prevented formation of perforin pores in target cells despite effective target cell engagement, as determined by calcium influx studies. Mouse PK studies of two analogues showed T1/2 values of 1.1-1.2 h (dose of 5 mg/kg iv) and MTDs of 60-80 mg/kg (ip).