897958-99-5

Basic information

• Product Name: 1H-Isoindol-1-one, 2,3-dihydro-5-iodo-
• Synonyms: 1H-Isoindol-1-one, 2,3-dihydro-5-iodo-;5-Iodo-2,3-dihydro-1H-isoindol-1-one;2,3-Dihydro-5-iodo-1H-isoindol-1-one;5-Iodo-2,3-dihydro-isoindol-1-one
• CAS NO: 897958-99-5
• Molecular Formula: C8H6INO
• Molecular Weight: 259.04381
• Mol File: 897958-99-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 465.1±45.0 °C at 760 mmHg
• Flash Point: 235.1±28.7 °C
• Appearance: /
• Density: 1.9±0.1 g/cm³
• Storage Temp.: 2-8°C
• PKA: 13.58±0.20(Predicted)
• CAS DataBase Reference: 1H-Isoindol-1-one, 2,3-dihydro-5-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 2,3-dihydro-5-iodo-(897958-99-5)
• EPA Substance Registry System: 1H-Isoindol-1-one, 2,3-dihydro-5-iodo-(897958-99-5)

Safety Data

• Hazardous Substances Data: 897958-99-5(Hazardous Substances Data)

Usage

General Description

1H-Isoindol-1-one, 2,3-dihydro-5-iodo- is a chemical compound with the molecular formula C8H6INO. It is a derivative of isoindolone and is classified as an iodinated organic compound. This chemical is used primarily in the field of organic synthesis and pharmaceutical research. It has potential applications in medicinal chemistry as a building block for the synthesis of biologically active molecules. The presence of the iodine atom in the compound provides unique reactivity and properties that make it valuable for the development of new drugs and materials. Additionally, it is also used as a reagent in various chemical reactions in the laboratory.

Upstream product

• 103440-53-5 4-iodo-2-methyl-benzoic acid methyl ester 
• 341011-40-3 methyl 2-(bromomethyl)-4-iodobenzoate 

Downstream Products

• 1313397-67-9 2-ethyl-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one 
• 1567836-85-4 2,4-difluoro-N-(2-methoxy-5-(5-(1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulphonamide 

Relevant articles and documents

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure-activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed 2-thioxoimidazolidin-4-one/thiophene core. The ability of the resulting compounds to inhibit the lytic activity of both isolated perforin protein and perforin delivered in situ by natural killer cells was determined. A number of compounds showed excellent activity at concentrations that were nontoxic to the killer cells, and several were a significant improvement on previous classes of inhibitors, being substantially more potent and soluble. Representative examples showed rapid and reversible binding to immobilized mouse perforin at low concentrations (≤2.5 μM) by surface plasmon resonance and prevented formation of perforin pores in target cells despite effective target cell engagement, as determined by calcium influx studies. Mouse PK studies of two analogues showed T1/2 values of 1.1-1.2 h (dose of 5 mg/kg iv) and MTDs of 60-80 mg/kg (ip).