Welcome to LookChem.com Sign In|Join Free
  • or

89796-99-6

Post Buying Request

89796-99-6 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Aceclofenac Manufacturer/High quality/Best price/In stock
Cas No: 89796-99-6
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications Aceclofenac CAS:89796-99-6
Cas No: 89796-99-6
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
CAS:89796-99-6 Aceclofenac hot sales
Cas No: 89796-99-6
No Data 1 Kilogram 100 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
Factory price Aceclofenac Cas 89796-99-6 with high quality and best price
Cas No: 89796-99-6
USD $ 45.0-50.0 / Kilogram 25 Kilogram 60 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High Quality 99% Aceclofenac;EP4 89796-99-6 GMP manufacturer
Cas No: 89796-99-6
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Aceclofenac CAS#89796-99-6
Cas No: 89796-99-6
USD $ 14.0-15.0 / Kilogram 25 Kilogram 50 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
Factory Supply Aceclofenac
Cas No: 89796-99-6
No Data 1 1 Ality Chemical Corporation Contact Supplier
Amadis Chemical offer CAS#89796-99-6;CAT#A843320
Cas No: 89796-99-6
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Supply 99% Aceclofenac Powder
Cas No: 89796-99-6
USD $ 30.0-35.0 / Kilogram 100 Kilogram 100 Kilogram/Day Arshine Pharmaceutical Co., Limited Contact Supplier
Aceclofenac
Cas No: 89796-99-6
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier

89796-99-6 Usage

Therapeutic Function

Analgesic, Antiinflammatory

Brand name

Airtal; Gerbin

Manufacturing Process

50 g of sodium 2-[(2,6-dichlorphenyl)amino]phenylacetate were dissolved in 300 ml of N,N-dimethylformamide under heating to 50°C, and 44.22 g of benzyl bromoacetate were added thereto. Under these condition stirring was continued for 9 hours. Upon completion of the reaction, the solvent was removed at reduced pressure, and the sodium salt were precipitated with addition of 400 ml of ether. The solution was then filtered and the ether phase was washed twice time with 100 ml of hexane. The resulting product was crystallized from the hexane/ether and then from acetone/chloroform (1:9) thus obtaining 44.1 g (61%) of benzyl 2-[(2,6- dichlorphenyl)amino]phenylacetoxyacetate in the form of white crystals having a melting point of 67-69°C. 45.28 g of benzyl 2-[(2,6-dichlorphenyl)amino]phenylacetoxyacetate were dissolved in 1500 ml of ethyl acetate, and the resulting solution was mixed with 7 g of Pd/C 10% and then hydrogen ted at atmospheric pressure for 14 hours. The solution was filtered, concentrated and crystallized; thereby obtaining 23.51 g (65%) of 2-[(2,6-dichlorphenyl)amino]phenylacetoxyacetic acid; melting point 149-150°C.

Description

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.

Chemical Properties

White Crystalline Solid

Mechanism of Action

Aceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.

Originator

Prodes (Prodesfarma) (Spain)

Description

Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.

Precautions

Before taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.

Uses

Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.

Definition

ChEBI: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
InChI:InChI=1/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

89796-99-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (A2484)  Aceclofenac  >98.0%(HPLC)(T) 89796-99-6 1g 385.00CNY Detail
TCI America (A2484)  Aceclofenac  >98.0%(HPLC)(T) 89796-99-6 5g 1,190.00CNY Detail
Sigma-Aldrich (Y0001094)  Aceclofenac for peak identification  European Pharmacopoeia (EP) Reference Standard 89796-99-6 Y0001094 1,880.19CNY Detail
Sigma (A8861)  Aceclofenac  ≥98% (HPLC) 89796-99-6 A8861-10MG 724.23CNY Detail
Sigma (A8861)  Aceclofenac  ≥98% (HPLC) 89796-99-6 A8861-50MG 2,925.00CNY Detail

89796-99-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name aceclofenac

1.2 Other means of identification

Product number -
Other names Zerodol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89796-99-6 SDS

89796-99-6Synthetic route

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester
139272-68-7

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester

aceclofenac
89796-99-6

aceclofenac

Conditions
ConditionsYield
With hydrogenchloride; acetic anhydride; acetic acid In water at 60℃; for 3h; Temperature;98.5%
With formic acid In acetone at 65℃; for 0.166667h; Reagent/catalyst; Solvent; Temperature; Microwave irradiation;96.3%
With aluminum (III) chloride; acetic anhydride; acetic acid at 60 - 65℃; for 2.5h; Reagent/catalyst; Temperature; Large scale;83%
With trifluoroacetic acid In dichloromethane at 20℃; for 7h;57%
With formic acid at 40℃;
tert-butyl-[2-(2,6-dichloroanilino) phenyl] acetoxy acetate

tert-butyl-[2-(2,6-dichloroanilino) phenyl] acetoxy acetate

aceclofenac
89796-99-6

aceclofenac

Conditions
ConditionsYield
With formic acid In toluene at 0 - 35℃; for 2h; Product distribution / selectivity;95%
With formic acid; trifluoroacetic acid In toluene at 25 - 40℃; for 2.5 - 5.5h; Product distribution / selectivity;
With formic acid In toluene at 0 - 50℃; for 2 - 4.5h; Product distribution / selectivity;
aceclofenac benzyl ester
100499-89-6

aceclofenac benzyl ester

aceclofenac
89796-99-6

aceclofenac

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal
diclofenac sodium
15307-79-6

diclofenac sodium

aceclofenac
89796-99-6

aceclofenac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide
2: H2 / Pd/C
View Scheme
Multi-step reaction with 2 steps
1: potassium iodide / acetonitrile / 0.25 h / 30 °C / Microwave irradiation
2: formic acid / acetone / 0.17 h / 65 °C / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: potassium iodide / ethanol / 3 h / 61 - 65 °C / Large scale
2: acetic acid; acetic anhydride; aluminum (III) chloride / 2.5 h / 60 - 65 °C / Large scale
View Scheme
C35H29Cl2NO10

C35H29Cl2NO10

aceclofenac
89796-99-6

aceclofenac

Conditions
ConditionsYield
With simulated intestinalfluid In methanol at 37℃; pH=7.4; Reagent/catalyst; pH-value; Solvent;
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

zirconyl nitrate

zirconyl nitrate

water
7732-18-5

water

aceclofenac
89796-99-6

aceclofenac

C28H22Cl2N3O6Zr(1+)*NO3(1-)*9H2O

C28H22Cl2N3O6Zr(1+)*NO3(1-)*9H2O

Conditions
ConditionsYield
With potassium hydroxide In acetone for 8h; Reflux;89.35%
aceclofenac
89796-99-6

aceclofenac

A

C16H13Cl2NO5

C16H13Cl2NO5

B

C14H11Cl2NO3

C14H11Cl2NO3

C

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester
15307-78-5

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

Conditions
ConditionsYield
In methanol at 20℃; for 6h; UV-irradiation;A 7%
B 5%
C 88%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

aceclofenac
89796-99-6

aceclofenac

C28H24Cl2CuN3O6(1+)*C2H3O2(1-)*6H2O

C28H24Cl2CuN3O6(1+)*C2H3O2(1-)*6H2O

Conditions
ConditionsYield
With potassium hydroxide In acetone for 8h; Reflux;80.04%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

nickel(II) acetate tetrahydrate
6018-89-9

nickel(II) acetate tetrahydrate

aceclofenac
89796-99-6

aceclofenac

C28H24Cl2N3NiO6(1+)*C2H3O2(1-)*3H2O

C28H24Cl2N3NiO6(1+)*C2H3O2(1-)*3H2O

Conditions
ConditionsYield
With potassium hydroxide In acetone for 8h; Reflux;78.08%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

lanthanide(III)chloride heptahydrate

lanthanide(III)chloride heptahydrate

aceclofenac
89796-99-6

aceclofenac

C28H24Cl2LaN3O6(2+)*9H2O*2Cl(1-)

C28H24Cl2LaN3O6(2+)*9H2O*2Cl(1-)

Conditions
ConditionsYield
With potassium hydroxide In acetone for 8h; Reflux;76.11%
4-acetaminophenol
103-90-2

4-acetaminophenol

aceclofenac
89796-99-6

aceclofenac

C24H20Cl2N2O5
1452834-52-4

C24H20Cl2N2O5

Conditions
ConditionsYield
With trichlorophosphate In pyridine at 5℃; for 4h;73%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

zinc(II) acetate dihydrate
5970-45-6

zinc(II) acetate dihydrate

aceclofenac
89796-99-6

aceclofenac

C28H24Cl2N3O6Zn(1+)*C2H3O2(1-)*3H2O

C28H24Cl2N3O6Zn(1+)*C2H3O2(1-)*3H2O

Conditions
ConditionsYield
With potassium hydroxide In acetone for 8h; Reflux;72.53%
ethanol
64-17-5

ethanol

aceclofenac
89796-99-6

aceclofenac

2-(2-[(2',6'-dichlorophenyl)amino]phenyl)acetoxyacetate

2-(2-[(2',6'-dichlorophenyl)amino]phenyl)acetoxyacetate

Conditions
ConditionsYield
With sulfuric acid for 6h; Reflux;65%
methanol
67-56-1

methanol

aceclofenac
89796-99-6

aceclofenac

C17H15Cl2NO4
139272-66-5

C17H15Cl2NO4

Conditions
ConditionsYield
With tert.-butylnitrite at 40℃; for 48h;63%
With sulfuric acid Reflux;
aceclofenac
89796-99-6

aceclofenac

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
4064-06-6

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

1,2,3,4-di-O-isopropylidene-D-α-galactopyranose-6-yl 2-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)acetic acid

1,2,3,4-di-O-isopropylidene-D-α-galactopyranose-6-yl 2-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)acetic acid

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;62%
{(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II)
38780-40-4, 52691-24-4, 61848-70-2, 61848-66-6, 61848-62-2

{(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II)

aceclofenac
89796-99-6

aceclofenac

C22H26Cl3N3O4Pt

C22H26Cl3N3O4Pt

Conditions
ConditionsYield
With sodium carbonate; silver nitrate In N,N-dimethyl-formamide at 20℃; for 24h; Darkness;50%
potassium ethyl methylmalonate
103362-70-5

potassium ethyl methylmalonate

aceclofenac
89796-99-6

aceclofenac

ethyl 4-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)-2-methyl-3-oxobutanoate

ethyl 4-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)-2-methyl-3-oxobutanoate

Conditions
ConditionsYield
Stage #1: aceclofenac With 1,1'-carbonyldiimidazole Inert atmosphere;
Stage #2: potassium ethyl methylmalonate With magnesium chloride Inert atmosphere;
43%
trans-2-pentenal
1576-87-0

trans-2-pentenal

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

tert-butyl N-tosyloxycarbamate
105838-14-0

tert-butyl N-tosyloxycarbamate

aceclofenac
89796-99-6

aceclofenac

tert-butyl (2S,3R)-2-{2-(tert-butylamino)-1-[2-(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetoxy]-2-oxoethyl}-3-ethylaziridine-1-carboxylate

tert-butyl (2S,3R)-2-{2-(tert-butylamino)-1-[2-(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetoxy]-2-oxoethyl}-3-ethylaziridine-1-carboxylate

Conditions
ConditionsYield
Stage #1: trans-2-pentenal; tert-butyl N-tosyloxycarbamate With (S)-α,α-bis(4-hexylphenylthio)-2-pyrrolidinemethanol trimethylsilylether; sodium carbonate In ethanol; water at 20℃; for 0.666667h; Green chemistry;
Stage #2: tert-butylisonitrile; aceclofenac In ethanol; water at 20℃; for 24h; Passerini Condensation; Green chemistry; diastereoselective reaction;
33%
2-nitroxyethylammonium nitrate
4665-58-1

2-nitroxyethylammonium nitrate

aceclofenac
89796-99-6

aceclofenac

(N-(2-(nitrooxy)ethyl)carbamoyl)methyl 2-(2-((2,6-dichlorophenyl)-amino)phenyl)acetate
183195-09-7

(N-(2-(nitrooxy)ethyl)carbamoyl)methyl 2-(2-((2,6-dichlorophenyl)-amino)phenyl)acetate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride13%
aceclofenac
89796-99-6

aceclofenac

[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions
ConditionsYield
With sodium hydroxide for 3h; Heating;
aceclofenac
89796-99-6

aceclofenac

4'-hydroxy aceclofenac

4'-hydroxy aceclofenac

Conditions
ConditionsYield
With NADPH-generating system In acetonitrile at 37℃; for 3h; pH=7.4; aq. phosphate buffer;
aceclofenac
89796-99-6

aceclofenac

β-cyclodextrine

β-cyclodextrine

aceclofenac-β-cyclodextrin (1:1) inclusion complex

aceclofenac-β-cyclodextrin (1:1) inclusion complex

Conditions
ConditionsYield
In methanol; water for 0.75h;
formaldehyd
50-00-0

formaldehyd

3,6-dinitro-9H-carbazole
3244-54-0

3,6-dinitro-9H-carbazole

aceclofenac
89796-99-6

aceclofenac

C29H20Cl2N4O8
1246212-64-5

C29H20Cl2N4O8

Conditions
ConditionsYield
In methanol Mannich reaction; Cooling with ice; Reflux;
3,6-dinitro-9H-carbazole
3244-54-0

3,6-dinitro-9H-carbazole

benzaldehyde
100-52-7

benzaldehyde

aceclofenac
89796-99-6

aceclofenac

C35H24Cl2N4O8
1246212-56-5

C35H24Cl2N4O8

Conditions
ConditionsYield
In methanol Mannich reaction; Cooling with ice; Reflux;
3,6-dinitro-9H-carbazole
3244-54-0

3,6-dinitro-9H-carbazole

aceclofenac
89796-99-6

aceclofenac

acetaldehyde
75-07-0

acetaldehyde

C30H22Cl2N4O8
1246212-52-1

C30H22Cl2N4O8

Conditions
ConditionsYield
In methanol Mannich reaction; Cooling with ice; Reflux;
3,6-dinitro-9H-carbazole
3244-54-0

3,6-dinitro-9H-carbazole

aceclofenac
89796-99-6

aceclofenac

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

C37H29Cl2N5O8
1246212-60-1

C37H29Cl2N5O8

Conditions
ConditionsYield
In methanol Mannich reaction; Cooling with ice; Reflux;
aceclofenac
89796-99-6

aceclofenac

2-chloro-2-oxoethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate
1227857-41-1

2-chloro-2-oxoethyl 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetate

Conditions
ConditionsYield
With thionyl chloride In benzene
With thionyl chloride at 20℃; for 18h; Temperature;
With thionyl chloride In tetrahydrofuran for 1.5h; Microwave irradiation;
aceclofenac
89796-99-6

aceclofenac

2-[(2,6-dichlorophenyl)amino]-N1-(phenyl)-N4-phenylacetoxyacetamidobenzenesulfonamide
1262333-96-9

2-[(2,6-dichlorophenyl)amino]-N1-(phenyl)-N4-phenylacetoxyacetamidobenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / benzene
2: N,N-dimethyl-formamide / 24 h / 10 - 130 °C
View Scheme

89796-99-6Upstream product

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 89796-99-6