89806-04-2

Upstream product

• 26152-32-9 pyridine-4-carbaldehyde methylthio(thiocarbonyl)hydrazone 
• 39577-51-0 2-methylsulphonyl-5-(4-pyridyl)-1,3,4-thiadiazole 
• 39577-53-2 4-[5-(methylsulfinyl)-1,3,4 thiadiazole-2-yl]pyridine 
• 89806-20-2 2-methylthio-5-(4-pyridyl)-1,3,4-thiadiazole 
• 89806-15-5 4-acetyl-2-methylsulphinyl-5-(4-pyridyl)-4,5-dihydro-1,3,4-thiadiazoles 
• 89806-17-7 4-acetyl-2-methylsulphonyl-5-(4-pyridyl)-4,5-dihydro-1,3,4-thiadiazole 
• 89806-03-1 4-acetyl-2-methylthio-5-(4-pyridyl)-4,5-dihydro-1,3,4-thiadiazole 

Downstream Products

• 111854-31-0 2-phenylthio-5-(1-oxido-4-pyridyl)-1,3,4-thiadiazole 
• 111854-33-2 2-anilino-5-(1-oxido-4-pyridyl)-1,3,4-thiadiazole 

Relevant academic research and scientific papers

A New Approach for Convenient One-pot Synthesis of 5-(1-Oxidopyridyl)- and 5-(1-Oxidoquinolyl)-2-alkylsulphonyl-1,3,4-thiadiazoles

Acetylation of pyridine-4-carbaldehyde methylthio(thiocarbonyl)hydrazone (1a) with acetic anhydride gave 4-acetyl-2-methylthio-5-(4-pyridyl)-4,5-dihydro-1,3,4-thiadiazole (2).Oxidation of compound (2) with 30percent hydrogen peroxide in acetic acid furnished 2-methylsulphonyl-5-(1-oxido-4-pyridyl)-1,3,4-thiadiazole (3a). 2-Alkylsulphonyl-1,3,4-thiadiazoles (3a-h) having 1-oxido-2-pyridyl, 1-oxido-3-pyridyl, 1-oxido-4-pyridyl, 1-oxido-2-quinolyl, and 1-oxido-4-quinolyl groups at the 5-position were obtained in good yields from the corresponding pyridine- (1a-f) and quinoline-carbaldehyde (1g) and (1h) alkylthio(thiocarbonyl)hydrazones by a one-pot synthesis.A reaction pathway from compound (2) to compound (3a) is also described.