89809-75-6

Usage

Functional groups

amino group, cyano group, methylphenyl group
Ethyl ester derivative of pyran-3-carboxylic acid
Potential applications in pharmaceutical industry
Suitable for use in drug development and medicinal chemistry
Further research required to fully understand properties and potential uses

Upstream product

• 24405-31-0 (Z)-ethyl 2-(4-methylbenzylidene)-3-oxobutanoate 
• 109-77-3 malononitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 2826-25-7 2-(4-methylbenzylidene)malononitrile 

Downstream Products

• 1394250-76-0 5-cyano-2-methyl-6-oxo-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Mesoporous KIT-6 supported ionic liquids as new and highly effective heterogeneous catalysts for three-component synthesis of 2-amino-3-cyano-4H-pyrans

A series of mesoporous KIT-6 supported ionic liquids were prepared and tested as effective and practical catalysts for the synthesis of 2-amino-3-cyano-4H-pyrans. The effects of type of catalysts, catalyst amount, and catalyst stability have also been inv

Choline chloride/pentaerythritol: a deep eutectic solvent for the synthesis of pyran and chromene derivatives

Abstract: A novel deep eutectic solvent system was prepared by mixing choline chloride as a hydrogen-bond acceptor with 2,2-bis(hydroxymethyl)propane-1,3-diol (pentaerythritol) as a hydrogen-bond donor. This green solvent was used for the one-pot synthesi

One-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles using sodium citrate as an organo-salt based catalyst in aqueous ethanol

Sodium citrate as a highly efficient catalyst is developed for the synthesis of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles. This method involves a one-pot three-component reaction of aromatic aldehydes, malononitrile and 1,3

Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs

Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact

A Novel Biopolymer-based Nanomagnetic Catalyst for the Synthesis of 4H-pyran and Tetrahydro-4H-chromene Derivatives

In the present study, we have designed and synthesized a new magnetically recoverable, nanocatalyst of Ag/Fe3O4?starch. The successful synthesis and the structure of the nanocatalyst were confirmed and evaluated with several analytical techniques including XRD, EDX, VSM, FT-IR, TEM and TGA. The impact and efficiency of Ag/Fe3O4?starch were successfully investigated in the one-pot synthesis of desired 4H-pyrans and tetrahydro-4H-chromenes using three-component condensation of various aldehydes, malononitrile, and 1,3-diketoesters or cyclic 1,3-diketones. The magnetic nanocatalyst was easily recovered and reused with high catalytic activity even after up to five runs.

Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media

Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc

Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation

A simple, effective and ecofriendly biocatalytic method has been developed to construct 2-amino-4H-pyrans via tandem multi-component reaction (MCR) of aldehyde, malononitrile and ethyl acetoacetate in one pot. The catalytic activity of lipases in differen

Synthesis of novel multi-OH functionalized ionic liquid and its application as dual catalyst-solvent for the one-pot synthesis 4H-pyrans

In the present work, triethanolammonium 3-hydroxypropane-1-sulfonate [TEA][HPS] as a novel multi-OH functionalized ionic liquid was synthesized. [TEA][HPS] was characterized by 1HNMR, 13CNMR, FT-IR and elemental analysis. In addition

Synthesis, biological evaluation and molecular docking study of 1,2,3-1H-triazoles having 4H-pyrano[2,3-d]pyrimidine as potential Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors

Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl acetoacetate. These heterocycles have been converted subsequently into 4H-pyrano[2,3-d]pyri

Synthesis method of 2-amino-4H-pyran and derivative of 2-amino-4H-pyran

The invention discloses a synthesis method of 2-amino-4H-pyran and a derivative of the 2-amino-4H-pyran. According to the method, candida rugosa lipase (CRL) is adopted as a catalyst to initiate a tandem MCR reaction, and 2-amino-4H-pyran is synthesized i