89809-78-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 105-07-7 4-cyanobenzaldehyde 
• 109-77-3 malononitrile 
• 89809-67-6 (Z)-ethyl 2-(4-cyanobenzylidene)-3-oxobutanoate 

Relevant academic research and scientific papers

Biocatalytic tandem multicomponent reactions for one-pot synthesis of 2-Amino-4H-Pyran library and in vitro biological evaluation

A simple, effective and ecofriendly biocatalytic method has been developed to construct 2-amino-4H-pyrans via tandem multi-component reaction (MCR) of aldehyde, malononitrile and ethyl acetoacetate in one pot. The catalytic activity of lipases in differen

Synthesis method of 2-amino-4H-pyran and derivative of 2-amino-4H-pyran

The invention discloses a synthesis method of 2-amino-4H-pyran and a derivative of the 2-amino-4H-pyran. According to the method, candida rugosa lipase (CRL) is adopted as a catalyst to initiate a tandem MCR reaction, and 2-amino-4H-pyran is synthesized i

Iodine catalyzed simple and efficient synthesis of antiproliferative 2-pyridones

A simple and efficient method for the selective synthesis of 2-pyrdones from 4H-pyrans using iodine as catalyst and ethanol as solvent was developed. The present method is equally effective for both aromatic and hetero aromatic ring containing 4H-pyrans.

Efficient and expeditious synthesis of pyrano-pyrimidines, multi-substituted γ-pyrans, and their antioxidant activity

An efficient, expeditious catalytic route for the synthesis of ethyl 6-amino-5-cyano-2-methyl-4-aryl-4H-pyran-3-carboxylates 2 was achieved via a three-component, one-pot reaction of malononitrile, ethyl acetoacetate, and various aromatic aldehydes in wat

A facile solvent-free one-pot three-component method for the synthesis of 2-amino-4H-pyrans and tetrahydro-4H-chromenes at ambient temperature

2-Amino-4H-pyrans and tetrahydro-4H-chromenes were readily prepared via a one-pot, three-component reaction of an aldehyde, malononitrile, and ethyl acetoacetate or 5,5-dimethyl-1,3-cyclohexanedione in the presence of anhydrous piperazine as an efficient

A heterogeneous strong basic Mg/La mixed oxide catalyst for efficient synthesis of polyfunctionalized pyrans

An efficient synthesis of polyfunctionalized 4H-pyrans is carried out in one pot through condensation of an aldehyde, malononitrile, and an active methylenic diketo compound using a heterogeneous strong basic Mg/La mixed oxide catalyst. The protocol offer

Tetramethylguanidine-[bmim][BF4]. An efficient and recyclable catalytic system for one-pot synthesis of 4H-pyrans

A clean and efficient method for the synthesis of 4H-pyran derivatives through the one-pot condensation of aromatic aldehydes, malononitriles, and β-dicarbonyl compounds, using guanidine base tetramethylguanidine in [bmim] [BF4] ionic liquid as

SYNTHESIS OF HETEROCYCLIC COMPOUNDS. XXXVI. PREPARATION OF ALKYL SUBSTITUTED PYRANCARBONITRLES.

The cyclization of the ketonitriles obtained from the reaction of suitably substituted propenones with propanedinitrile leads to alkyl substituted 4H-pyrans.Some of the starting propenones had to be prepared by base promoted opening of an isoxazole ring in the presence of an aldehyde.An exception to the general synthesis is also reported.