89809-79-0

Usage

Main properties

chemical compound, organic synthesis, medicinal chemistry

Class

pyran derivatives

Solubility

more soluble in organic solvents due to ethyl ester form

Use

building block for synthesis of pharmaceuticals and agrochemicals

Potential

medicinal applications due to amino and cyano groups

Potential fields

drug discovery, chemical synthesis

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 3138-23-6 2-(3,4-dichlorobenzylidene)malononitrile 
• 24393-32-6 cis-2-(3,4-Dichlor-benzyliden)-acetessigsaeure-aethylester 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

A convenient and clean procedure for the synthesis of pyran derivatives in aqueous media catalysed by TEBAC

A clean and simple synthesis of 6-amino-5-cyano-4-aryl-2-methyl-4H-pyran-3- carboxylate derivatives was accomplished in high yields via the reaction of arylmethylidenemalononitriles with acetoacetate in aqueous media catalysed by triethylbenzylammonium ch

SYNTHESIS OF HETEROCYCLIC COMPOUNDS. XXXVI. PREPARATION OF ALKYL SUBSTITUTED PYRANCARBONITRLES.

The cyclization of the ketonitriles obtained from the reaction of suitably substituted propenones with propanedinitrile leads to alkyl substituted 4H-pyrans.Some of the starting propenones had to be prepared by base promoted opening of an isoxazole ring in the presence of an aldehyde.An exception to the general synthesis is also reported.