89809-92-7

Upstream product

• 108-94-1 cyclohexanone 
• 614-16-4 Benzoylacetonitrile 

Downstream Products

• 89809-97-2 2-amino-3,5-dicyano-6-phenyl-4H-pyran-4-spirocyclohexane 
• 1271933-31-3 (2'RS)-3',4',3'',4'',5'',6''-hexahydro-6'-phenyldispiro[cyclohexane-1,4'-[2H]pyran-2',2''-[2H]pyran]-5'-carbonitrile 
• 1271933-10-8 (2'RS)-3',4'-dihydro-2'-isobutoxy-6'-phenylspiro[cyclohexane-1,4'-[2H]pyran]-5'-carbonitrile 
• 1271933-12-0 (2'RS)-3',4'-dihydro-2'-methoxy-2'-methyl-6'-phenylspiro[cyclohexane-1,4'-[2H]pyran]-5'-carbonitrile 
• 1271933-08-4 (2'RS)-2'-ethoxy-3',4'-dihydro-6'-phenylspiro[cyclohexane-1,4'-[2H]pyran]-5'-carbonitrile 

Relevant academic research and scientific papers

Knoevenagel condensation of cyclic ketones with benzoylacetonitrile and N,N′-dimethylbarbituric acid. Application of sterically hindered condensation products in the synthesis of spiro and dispiropyrans by hetero-Diels-Alder reactions

Inverse-electron demand Diels-Alder cycloadditions of sterically hindered cycloalkylidene derivatives of benzoylacetonitrile and N,N′- dimethylbarbituric acid with enol ethers, cyclic enol ethers and also sterically hindered cycloalkylidenecycloalkanes we

SYNTHESIS OF HETEROCYCLIC COMPOUNDS. XXXVI. PREPARATION OF ALKYL SUBSTITUTED PYRANCARBONITRLES.

The cyclization of the ketonitriles obtained from the reaction of suitably substituted propenones with propanedinitrile leads to alkyl substituted 4H-pyrans.Some of the starting propenones had to be prepared by base promoted opening of an isoxazole ring in the presence of an aldehyde.An exception to the general synthesis is also reported.