89811-41-6Relevant academic research and scientific papers
INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS
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Page/Page column 38; 45; 46, (2017/12/18)
This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.
REACTION OF AMINONITRENES WITH AZO COMPOUNDS. I. REACTION OF PHTHALIMIDONITRENE WITH ALKANEAZOBENZENES
Kuznetsov, M. A.,Suvorov, A. A.
, p. 2260 - 2269 (2007/10/02)
The reaction of phthalimidonitrene with the simplest alkaneazobenzenes leads to the formation of pairs of stereoisomeric 2-alkyl-3-phenyl-1-phthalimidoazimines differing in the configuration at the N2N3 bond; the isomeric 3-alkyl-2-phenyl-1-phthalimidoazimines were not found in the reaction mixtures.The individual stereoisomers of the 2-alkyl-3-phenyl-1-phthalimidoazimines are stable in the solid state at room temperature, but in solutions they are slowly converted into an equilibrium mixture of the isomers; when heated, they release nitrogen with the formation of 2-alkyl-3-phenyl-2,3-dihydrophthalazine-1,4-diones.
