89812-79-3

Upstream product

• 189750-69-4 11-chloropyrrolo[2,1-c][1,4]benzodiazepine 
• 89812-71-5 N-(2-Methoxycarbonylphenyl)-pyrrole-2-thiocarboxamide 
• 89812-76-0 2-(2-Pyrrolyl)-4H-3,1-benzothiazin-4-one 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 
• 50424-51-6 (2R,11aS)-2-hydroxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione 
• 24919-45-7 (2RS,4SR)-1,2,3,4,5,6-hexahydro-2-hydroxypyrrolo[2,1-c][1,4]benzodiazepine-5,11(12H)-dione 
• 76447-29-5 5,11-Dioxo-10,11-dihydro-5H-pyrrolo<2,1-c><1,4>benzodiazepine 
• 89812-75-9 N-(2-Carboxyphenyl)-pyrrole-2-thiocarboxamide 
• 89812-78-2 2-(2-Pyrrolyl)-4H-3,1-benzoxazin-4-one 

Relevant academic research and scientific papers

Synthesis of novel benzo[h][1,6]naphthyridines via a rearrangement of hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepines

Heating of hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-2,5,11-trione in boiling phosphoryl chloride led to a rearranged product like 3,5-dichlorobenzo[h][1,6]naphthyridine. This structure was established from x-ray diffraction analysis.

An expedient route to aromatic pyrrolo[2,1-c][1,4]benzodiazepines and a study of their reactivity

2-Hydroxypyrrolo[2,1-c][1,4]benzodiazepines were aromatised in refluxing thionyl chloride into 11-chloropyrrolo[2,1-c][1,4]benzodiazepines in high yield. This aromatic system is doubly reactive towards nucleophiles leading to rearranged products such as i