89821-48-7

Basic information

• Product Name: Boc-Leu-Orn(Z)-Leu-Orn(Z)-Leu-D-Phe-Sar-OEt
• Synonyms: Boc-Leu-Orn(Z)-Leu-Orn(Z)-Leu-D-Phe-Sar-OEt
• CAS NO: 89821-48-7
• Molecular Weight: 1200.48
• Mol File: 89821-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Leu-Orn(Z)-Leu-Orn(Z)-Leu-D-Phe-Sar-OEt(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Leu-Orn(Z)-Leu-Orn(Z)-Leu-D-Phe-Sar-OEt(89821-48-7)
• EPA Substance Registry System: Boc-Leu-Orn(Z)-Leu-Orn(Z)-Leu-D-Phe-Sar-OEt(89821-48-7)

Safety Data

• Hazardous Substances Data: 89821-48-7(Hazardous Substances Data)

Upstream product

• 88472-52-0 Boc-Leu-Orn(Z)-N₃ 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 2411-94-1 Orn(δ-Z)-OEt*p-TosOH 
• 88472-41-7 Boc-Leu-Orn(Z)-OEt 
• 88472-42-8 Boc-Leu-Orn(Z)-NHNH₂ 
• 89821-44-3 Boc-Leu-Orn(Z)-Leu-D-Phe-Sar-OEt 

Downstream Products

• 89821-50-1 Boc-Leu-Orn(Z)-Leu-Orn(Z)-Leu-D-Phe-Sar-NHNH₂ 

Relevant articles and documents

Studies of peptide antibiotics. XLV. Syntheses of gramicidin S-like analogs with macro-ring structures

Three cyclic tetradecapeptides related to gramicidin S (GS) were synthesized to investigate the contributions of the ring size of cyclic peptides and of the number of the basic amino acid residues to the antibacterial activity. The protected cyclic tetradecapeptides were synthesized through a cyclization reaction of the linear tetradecapeptide azide in pyridine. Hydrogenolysis of the protected cyclic peptides afforded crystalline tetrahydrochlorides of the analogs. The homogeneity of the analogs was ascertained by TLC, paper electrophoresis, and elemental analysis. In the experiment of circular dichroism, the two analogs with 7,7 prime -Pro or 7,7 prime -Sar gave spectra similar in shape to that of GS, while the analog with 7,7 prime -Gly gave a slightly different spectrum from that of GS.