898253-17-3Relevant articles and documents
Preparation of (S)-tert-butylpyox and palladium-catalyzed asymmetric conjugate addition of arylboronic acids
Sardini, Stephen R.,Stoltz, Brian M.
, p. 117 - 130 (2021/06/18)
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Pyridine-Hydrazone Ligands in Asymmetric Palladium-Catalyzed 1,4- and 1,6-Additions of Arylboronic Acids to Cyclic (Di)enones
de Gracia Retamosa, María,álvarez-Casao, Yolanda,Matador, Esteban,Gómez, ángela,Monge, David,Fernández, Rosario,Lassaletta, José M.
, p. 176 - 184 (2018/12/11)
Catalysts generated by combinations of Pd(TFA)2 and enantiomerically pure pyridine-hydrazone ligands have been applied to the 1,4-addition of arylboronic acids to β-substituted cyclic enones, building all-carbon quaternary stereocenters in high
Palladium-Catalyzed Conjugate Addition of Arylboronic Acids to β,β-Disubstituted Enones in Aqueous Media: Formation of Bis-benzylic and ortho-Substituted Benzylic Quaternary Centers
Van Zeeland, Ryan,Stanley, Levi M.
, p. 5203 - 5206 (2015/09/15)
Palladium-catalyzed conjugate addition of arylboronic acids to β,β-disubstituted enones in aqueous media is reported. Additions of a wide range of arylboronic acids to β,β-disubstituted enones occur to form ketone products bearing benzylic all-carbon quaternary centers. These reactions are promoted by a simple catalyst prepared from palladium trifluoracetate and 2,2′-bipyridine. The use of aqueous sodium trifluoracetate as the reaction medium significantly enhances reactivity and enables the formation of challenging bis-benzylic and ortho-substituted benzylic all-carbon quaternary centers.
