898269-49-3

Basic information

• Product Name: C₃₁H₆₄O₂Si₂
• Synonyms: C₃₁H₆₄O₂Si₂
• CAS NO: 898269-49-3
• Molecular Weight: 525.019
• Mol File: 898269-49-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₆₄O₂Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₆₄O₂Si₂(898269-49-3)
• EPA Substance Registry System: C₃₁H₆₄O₂Si₂(898269-49-3)

Safety Data

• Hazardous Substances Data: 898269-49-3(Hazardous Substances Data)

Upstream product

• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 

Relevant articles and documents

HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS

The present invention discloses a series of new carbonyl side chain anlogs of calcitriol (I). Unexpectedly, several of these ketone analogs, such as the 24- and 25-tert-butyl ketones, amides, hydroxymate esters and a hetero atom ketones even though lacking the classical side-chain tertiary hydroxyl group, are considerably more antiproliferative in vitro than the hormone calcitriol (I) even at physiologically relevant low nanomolar concentrations and are less calcemic than calcitriol (I) in vivo.