898276-48-7Relevant academic research and scientific papers
Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with α,β-unsaturated aldehydes
Gotoh, Hiroaki,Ishikawa, Hayato,Hayashi, Yujiro
, p. 5307 - 5309 (2008/09/17)
(Chemical Equation Presented) A catalytic enantioselective direct conjugate addition of nitroalkanes to α,β-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst has been developed. Using this methodology as a key step, short syntheses of therapeutically useful compounds have also been accomplished.
