89848-41-9

Basic information

• Product Name: N-Desalkyl Itraconazole
• Synonyms: N-Desalkyl Itraconazole;cis-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
• CAS NO: 89848-41-9
• Molecular Formula: C₃₁H₃₀Cl₂N₈O₄
• Molecular Weight: 649.5271
• EINECS: -0
• Product Categories: Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 89848-41-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Very Slightly, Heated)
• CAS DataBase Reference: N-Desalkyl Itraconazole(CAS DataBase Reference)
• NIST Chemistry Reference: N-Desalkyl Itraconazole(89848-41-9)
• EPA Substance Registry System: N-Desalkyl Itraconazole(89848-41-9)

Safety Data

• Hazardous Substances Data: 89848-41-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 89848-41-9 differently. You can refer to the following data:
1. N-Desalkyl Itraconazole is a derivative of itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.
2. N-Desalkyl Itraconazole is a derivative of itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.

Upstream product

• 3473-63-0 formamidine acetic acid 
• 89848-13-5 cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide 

Downstream Products

• 89848-56-6 2-Cyclopentyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one 
• 89848-55-5 4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-(3-methyl-butyl)-2,4-dihydro-[1,2,4]triazol-3-one 
• 89848-54-4 2-Allyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one 
• 89848-57-7 2-Cyclopropylmethyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one 
• 84625-61-6 itraconazole 

Relevant articles and documents

Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones

A series of novel triazol-3-ones has been synthesized, and their in vitro and in vivo antifungal properties are reported. Traconazole. which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.