Cas 898538-19-7,2-(5-bromo-2-chlorobenzyl)-1-benzothiophene

898538-19-7

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Basic information

Product Name: 2-(5-bromo-2-chlorobenzyl)-1-benzothiophene
Synonyms: 2-(5-bromo-2-chlorobenzyl)-1-benzothiophene
CAS NO:898538-19-7
Molecular Formula:
Molecular Weight: 337.667
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 2-(5-bromo-2-chlorobenzyl)-1-benzothiophene(CAS DataBase Reference)
NIST Chemistry Reference: 2-(5-bromo-2-chlorobenzyl)-1-benzothiophene(898538-19-7)
EPA Substance Registry System: 2-(5-bromo-2-chlorobenzyl)-1-benzothiophene(898538-19-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 898538-19-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 898538-19-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,8,5,3 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 898538-19:
(8*8)+(7*9)+(6*8)+(5*5)+(4*3)+(3*8)+(2*1)+(1*9)=247
247 % 10 = 7
So 898538-19-7 is a valid CAS Registry Number.

898538-19-7Upstream product

898538-19-7Downstream Products

898538-19-7Relevant academic research and scientific papers

Bicyclic derivative of heterocyclic glucoside as well as preparation method and application of bicyclic derivative

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, (2021/07/21)

The invention relates to a bicyclic derivative of heterocyclic glucoside as well as a preparation method and application of the bicyclic derivative, in particular to a compound shown in a formula I, a stereoisomer or pharmaceutically acceptable salt or es

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

Imamura, Masakazu,Nakanishi, Keita,Suzuki, Takayuki,Ikegai, Kazuhiro,Shiraki, Ryota,Ogiyama, Takashi,Murakami, Takeshi,Kurosaki, Eiji,Noda, Atsushi,Kobayashi, Yoshinori,Yokota, Masayuki,Koide, Tomokazu,Kosakai, Kazuhiro,Ohkura, Yasufumi,Takeuchi, Makoto,Tomiyama, Hiroshi,Ohta, Mitsuaki

, p. 3263 - 3279 (2012/07/14)

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity against SGLT2 and good selectivity versus SGLT1. Through further optimization of 14a, a novel benzothiophene derivative (14h; ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

Novel SGLT inhibitors

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Page/Page column 40, (2008/06/13)

Novel compounds of formula (A) or a pharmaceutically acceptable salt thereof: wherein symbols are as defined in claims, which are useful as SGLT inhibitors and for treatment of diabetes and related diseases.

1-THIO-D-GLUCITOL DERIVATIVES

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Page/Page column 36-37, (2010/11/28)

The present invention provides a 1-thio-D-glucitol compound of the following formula, which shows the action of inhibiting the activity of SGLT2, a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the salt; and a pharmaceu

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