898538-92-6

Basic information

• Product Name: ethyl 3-[2-(2-hydroxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-4-pentenoate
• Synonyms: ethyl 3-[2-(2-hydroxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-4-pentenoate
• CAS NO: 898538-92-6
• Molecular Weight: 336.428
• Mol File: 898538-92-6.mol

Chemical Properties

• CAS DataBase Reference: ethyl 3-[2-(2-hydroxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-4-pentenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-[2-(2-hydroxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-4-pentenoate(898538-92-6)
• EPA Substance Registry System: ethyl 3-[2-(2-hydroxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-4-pentenoate(898538-92-6)

Safety Data

• Hazardous Substances Data: 898538-92-6(Hazardous Substances Data)

Upstream product

• 898538-91-5 3-[2-(2-hydroxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-prop-2-en-1-ol 
• 78-39-7 Triethyl orthoacetate 
• 75786-73-1 6-hydroxy-7-methyl-2H-chromen-2-one 
• 898538-86-8 3-[2-(1-carboxy-1-methyl-ethoxy)-5-methoxy-4-methyl-phenyl]-acrylic acid 
• 898538-88-0 methyl 3-[5-methoxy-2-(1-methoxycarbonyl-1-methyl-ethoxy)-4-methylphenyl]-acrylate 
• 55939-26-9 6-methoxy-7-methylcoumarin 
• 960367-63-9 ethyl 3-[2-(2-acetoxy-1,1-dimethylethoxy)-5-methoxy-4-methylphenyl]-4-pentenoate 

Downstream Products

• 898538-85-7 ethyl 3-[5-methoxy-2-(1-methoxycarbonyl-1-methyl-ethoxy)-4-methylphenyl]-4-pentenoate 
• 898538-94-8 3-[2-(1-carboxy-1-methyl-ethoxy)-5-methoxy-4-methyl-phenyl]-pent-4-enoic acid ethyl ester 

Relevant articles and documents

Bargellini condensation of coumarins. Expeditious route to o-carboxyvinylphenoxyisobutyric acids and application to the synthesis of sesquiterpenes helianane, heliannuol A and heliannuol C

The direct Bargellini condensation of coumarins involving reaction with chloroform and acetone in the presence of aqueous sodium hydroxide furnished o-carboxyvinylphenoxyisobutyric acids in good yields. The utility of this new useful protocol was demonstrated by the transformation of the three diesters 9b, 9f and 9g to the sesquiterpenes helianane 4, heliannuol A 2 and heliannuol C 3, respectively.

The synthesis of heliannuol C, an allelochemical from Helianthus annuus

The synthesis of the allelochemical heliannuol C 1 is described by employing a Bargellini condensation and a Claisen rearrangement to install the gem-dimethyl and vinyl functionalities, respectively. A Dieckmann cyclisation of diester 11 enabled the gener