898552-64-2

Upstream product

• 46193-76-4 ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate 
• 35355-50-1 ethyl 2-azido-3-(thiophen-2-yl)acrylate 
• 898552-84-6 2-(4-nitrophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Rigidified Compounds for Modulating Heparanase Activity

Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these compounds, as defined in the specification, is characterized as having one or zero free-to-rotate bonds. Also disclosed are pharmaceutical compositions containing these rigidified compounds and uses thereof for modulating the activity of heparanase and hence in the treatment of heparanase-associated diseases and disorders, and uses thereof for modulating the activity of heparin-binding proteins and hence in the treatment of heparin-binding proteins-associated diseases and disorders as well as in the treatment of medical conditions that are at least partially treatable by rhodanine or a rhodanine analog.