898563-86-5

Upstream product

• 171001-06-2 1-(4-(benzyloxy)phenyl)-2-(pyridin-4-yl)ethanone 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 1301167-63-4 4-(3-(4-(benzyloxy)phenyl)-1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyridine 
• 1301167-64-5 4-[5-(4-benzyloxyphenyl)-1-(2-fluoroethyl)-1H-pyrazol-4-yl]pyridine 
• 1301168-29-5 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,4,5-trimethylpyridine succinic acid 
• 1301168-25-1 2-ethoxy-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid 
• 1301168-23-9 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-6-methoxypyridine succinic acid 
• 1301168-11-5 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid 
• 1301167-90-7 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-5-methoxypyridine 
• 1301167-97-4 2-cyclopropyl-6-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]pyridine succinic acid 
• 1301167-85-0 2-[4-[1-(3-fluoropropyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-6-methylpyridine hydrochloric acid 
• 1301167-87-2 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine 
• 1301167-88-3 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,5-dimethylpyridine succinic acid 
• 1320293-12-6 6-[4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxymethyl]pyridin-3-ol 
• 1301168-28-4 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3,4,5-trimethylpyridine 
• 1301168-27-3 3-bromo-2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-6-methoxypyridine 

Relevant academic research and scientific papers

RADIOLABELLED PDE10 LIGANDS

The present invention relates to novel, selective, radiolabelled PDE10 ligands which are useful for imaging and quantifying the PDE10A enzyme in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo.

BICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS

The invention pertains to bicyclic heteroaryl compounds that serve as effective phosphodiesterase (PDE) inhibitors The invention also relates to compounds which are selective inhibitors of PDE-10. The invention further relates to intermediates for prepara

Heteroaromatic quinoline compounds

The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.