898732-73-5Relevant academic research and scientific papers
SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS
-
Page/Page column 35, (2013/06/27)
The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particulalrly FabI inhibitors. Formula(I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
Synthesis of an unnatural product - 4,4′ biaryl formation as a macrocyclisation step
Patel, Hitesh K.,Kilburn, Jeremy D.,John Langley,Edwards, Peter D.,Mitchell, Tim,Southgate, Robert
, p. 481 - 484 (2007/10/02)
A novel macrocycle featuring a crown ether ring, amide functionality and a rigid biaryl unit has been prepared as a potential receptor for small peptidic guests. The synthesis of the macrocycle includes a palladium catalysed biaryl formation as the ring-closing step.
