898758-82-2Relevant academic research and scientific papers
The new method of the preparation of oxazole derivatives
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Paragraph 0030; 0031; 0032, (2017/08/25)
The invention particularly relates to a method for synthesizing oxazole derivative, belonging to the field of synthesis of heterocyclic compounds. The technical scheme is as follows: the method comprises the following steps: reacting the raw material tosyl methyl isonitrile derivative disclosed as Formula (I) with acyl chloride disclosed as Formula (II) to obtain alpha-ketoimine chloride disclosed as Formula (III); and reacting the intermediate alpha-ketoimine chloride disclosed as Formula (III) with aldehyde (IV) in the presence of a protonic solvent and alkali to obtain 2-substituted oxazole (V). Compared with the prior art, the method uses cheap and accessible raw materials, avoids using the catalyst, lowers the cost, reduces the environmental pollution, has the advantage of mild reaction conditions, and is simple to operate and beneficial to industrial production.
PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
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Page/Page column 93, (2009/07/18)
The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and / or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
