898798-99-7Relevant academic research and scientific papers
Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4
Blackburn, Christopher,Guan, Bing,Brown, James,Cullis, Courtney,Condon, Stephen M.,Jenkins, Tracy J.,Peluso, Stephane,Ye, Yingchun,Gimeno, Ruth E.,Punreddy, Sandhya,Sun, Ying,Wu, Hui,Hubbard, Brian,Kaushik, Virendar,Tummino, Peter,Sanchetti, Praveen,Yu Sun, Dong,Daniels, Tom,Tozzo, Effie,Balani, Suresh K.,Raman, Prakash
, p. 3504 - 3509 (2007/10/03)
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO2 and CF3) of the 4-aryl group led to active compounds. In two cases racemates were resolved and the S enantiomers shown to have higher potencies.
