898799-38-7Relevant academic research and scientific papers
Practical, catalytic, asymmetric synthesis of β-lactones via a sequential ketene dimerization/hydrogenation process: Inhibitors of the thioesterase domain of fatty acid synthase
Purohit, Vikram C.,Richardson, Robyn D.,Smith, Jeffrey W.,Romo, Daniel
, p. 4549 - 4558 (2007/10/03)
The recent finding that the PDA-approved antiobesity agent orlistat (tetrahydrolipstatin, Xenical) is a potent inhibitor of the thioesterase domain of fatty acid synthase (FAS) led us to develop a concise and practical asymmetric route to pseudosymmetric
