89892-33-1

Upstream product

• 15790-59-7 3,5-dibromo-2-methoxy-benzoic acid methyl ester 
• 3147-55-5 3,5-dibromosalicylic acid 

Downstream Products

• 121789-25-1 1-(3,5-Dibrom-2-methoxyphenyl)-3-(1,3-dioxolan-2-yl)-1-propanon 
• 152565-59-8 2-(3',5'-Dibrom-2'-methoxybenzoyl)-1H-pyrrol 
• 81268-68-0 N-(1H-Benzoimidazol-2-yl)-3,5-dibromo-2-methoxy-benzamide 
• 121789-27-3 1-(3,5-Dibrom-2-hydroxyphenyl)-3-(1,3-dioxan-2-yl)-1-propanon 
• 121789-28-4 1-(3,5-Dibrom-2-methoxyphenyl)-3-(1,3-dioxan-2-yl)-1-propanon 
• 98527-10-7 (S)-(-)-3,5-dibromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]salicylamide 
• 2577-72-2 3,5-dibromo-2-hydroxy-N-phenylbenzamide 
• 121789-72-8 2,7,12-Tris-(3,5-dibrom-2-methoxyphenyl)-4,4a,9,9a,14,14a-hexahydro-3H,8H,13H-tripyradizino<1,6-a:1',6'-c:1',6'-e>-s-triazin 
• 121789-67-1 1,4-Bis(3,5-dibrom-2-methoxyphenyl)-2-methylisoindol 
• 121789-74-0 2-Acetyl-5-(3,5-dibrom-2-methoxyphenyl)-1-phenylsulfonylpyrrol 
• 121789-73-9 2-(3,5-Dibrom-2-methoxyphenyl)-1-phenylsulfonylpyrrol 
• 121789-71-7 2,3,4-Tribrom-5-(3,5-dibrom-2-methoxyphenyl)-1-methylpyrrol 
• 121789-70-6 5-(3,5-Dibrom-2-methoxyphenyl)-2-iod-1-methylpyrrol 
• 121789-77-3 2-Brom-5-(3,5-dibrom-2-methoxyphenyl)thiophen 

Relevant academic research and scientific papers

Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus

We recently reported the identification of a GroEL/ES inhibitor (1, N-(4-(benzo[d]thiazol-2-ylthio)-3-chlorophenyl)-3,5-dibromo-2-hydroxybenzamide) that exhibited in vitro antibacterial effects against Staphylococcus aureus comparable to vancomycin, an antibiotic of last resort. To follow up, we have synthesized 43 compound 1 analogs to determine the most effective functional groups of the scaffold for inhibiting GroEL/ES and killing bacteria. Our results identified that the benzothiazole and hydroxyl groups are important for inhibiting GroEL/ES-mediated folding functions, with the hydroxyl essential for antibacterial effects. Several analogs exhibited >50-fold selectivity indices between antibacterial efficacy and cytotoxicity to human liver and kidney cells in cell culture. We found that MRSA was not able to easily generate acute resistance to lead inhibitors in a gain-of-resistance assay and that lead inhibitors were able to permeate through established S. aureus biofilms and maintain their bactericidal effects.

A cyclotrimethoxone-substituted salicylate compound and anti-tumor effect thereof

The invention relates to the technical field of medicines, and designs and synthesizes a novel A cyclotrimethoxy 4'-hydroxyflavone compound and an A cyclotrimethoxone-substituted salicylate compound. The figure 1 is a general formula of the A cyclotrimethoxone-substituted salicylate compound, wherein in the formula, R1, R2 and R3 are equal to OCH3 or R2, R3 and R4 are equal to OCH3; R5- is equal to OCH3, CH3, F, Cl, Br, I or the like. The novel A cyclotrimethoxy 4'-hydroxyflavone compound and the A cyclotrimethoxone-substituted salicylate compound can have an obvious inhibiting effect on MGC-803 (human gastric carcinoma cells), HepG2 (human hepatoma carcinoma cells), MCF-7 (human breast cancer cells) and hopefully become anti-tumor drugs. The invention discloses a preparation method of the novel A cyclotrimethoxy 4'-hydroxyflavone compound and the A cyclotrimethoxone-substituted salicylate compound.

Marine Bacteria, I. - Synthesis of Pentabromopseudiline, a Cytotoxic Phenylpyrrole from Alteromonas luteo-violaceus

A new synthesis of 2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)pyrrole (1a, pentabromopseudiline), an antibiotic, enzymeinhibitory and cytotoxic active constituent of the marine bacterium Alteromonas luteo-violaceus, is described.For investigation of structure-activity relationships further 2-phenylpyrroles are investigated.Key step in their synthesis is the Grignard reaction of 2-(1,3-dioxan-2-yl)ethylmagnesium bromide (9d) with benzoyl chlorides yielding γ-phenyl-γ-ketoaldehydes 24, and the Paal-Knorr cyclisation of the latter. - Key Words: Alteromonas luteo-violaceus / Bromopyrrole / Marine bacteria / Pentabromopseudiline