89909-51-3Relevant academic research and scientific papers
Indolin-2-ones with high in vivo efficacy in a model for multiple sclerosis
Bouérat, La?titia,Fensholdt, Jef,Liang, Xifu,Havez, Sophie,Nielsen, Simon F.,Hansen, Jens R.,Bolvig, Simon,Andersson, Christina
, p. 5412 - 5414 (2005)
The known KDR inhibitor SU5416 and several analogues of the indolin-2-one family were surprisingly found to be highly efficacious in the EAE model, an established model for multiple sclerosis. The high in vivo effect could be correlated to in vitro inhibi
TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES
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Page/Page column 19; 20; 30; 31, (2016/11/17)
Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of t
Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials
Kancharla, Papireddy,Kelly, Jane Xu,Reynolds, Kevin A.
, p. 7286 - 7309 (2015/10/05)
Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh
NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES
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Page/Page column 62, (2010/02/12)
Certain oxindole compounds have been found to be effective in experimentally induced autoimmune encephalitis and are therefore suggested for the preparation of a medicament for the prevention, treatment or amelioration of multiple sclerosis, or to delay the onset of or reduce the relapse rate in multiple sclerosis.
