89938-56-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-4-Methoxysalicylaldehyde is used as an intermediate for the synthesis of various organic compounds, contributing to the development of new pharmaceutical products.
Used in Agrochemical Industry:
5-Chloro-4-Methoxysalicylaldehyde is also utilized as an intermediate in the agrochemical industry, aiding in the synthesis of various agrochemicals.
Used in Anti-Inflammatory Applications:
5-Chloro-4-Methoxysalicylaldehyde is used as an anti-inflammatory agent, potentially offering therapeutic benefits in treating inflammation-related conditions.
Used in Antimicrobial Applications:
It serves as an antimicrobial agent, providing a means to combat microbial infections.
Used in Fluorescent Sensor and Dye Development:
5-Chloro-4-Methoxysalicylaldehyde is used in the development of fluorescent sensors and dyes, due to its potential applications in research and analytical chemistry.

Upstream product

• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 50-00-0 formaldehyd 
• 18113-07-0 4-Chloro-3-methoxyphenol 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 95-88-5 4-Chlororesorcinol 

Downstream Products

• 194488-05-6 (Z)-1-acetyl-3-(5-chloro-2-hydroxy-4-methoxy)benzylidene-2,5-piperazinedione 
• 1106538-44-6 4-chloro-2-(1-hydroxy-2-methyl-propyl)-5-methoxy-phenol 
• 1309612-66-5 C₂₆H₂₄ClN₃O₆ 
• 1106538-74-2 4-chloro-2-(hydroxy-phenyl-methyl)-5-methoxy-phenol 

Relevant academic research and scientific papers

MICROBIOCIDALLY ACTIVE BENZOXABOROLES

Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

2,2,6,6-Tetramethylpiperidine-catalyzed, ortho-selective chlorination of phenols by sulfuryl chloride

2,2,6,6-Tetramethylpiperidine (TMP)-catalyzed (1- 10%) chlorinations of phenols by SO2Cl2 in aromatic solvents are more ortho selective than with primary and less hindered secondary amine catalysts. Ortho-selective chlorination is successful even with electron deficient phenols such as 2-hydroxybenzaldehyde and 2'- hydroxyacetophenone. Notably, ortho selectivity increases with the reaction temperature. On the other hand, tetraalkylammonium chloride-catalyzed chlorinations are moderately para selective.

IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments.

Syntheses of chloroisosulochrin and isosulochrin and biomimetic elaboration to maldoxin, maldoxone, dihydromaldoxin, and dechlorodihydromaldoxin

An efficient synthesis of chloroisosulochrin was accomplished using a novel ortho-selective chlorination of a phenol with sulfuryl chloride and 2,2,6,6-tetramethylpiperidine as the key step. Further elaboration by a biomimetic route converted chloroisosul

Synthesis and evaluation of self-calibrating ratiometric viscosity sensors

We describe the design, synthesis and fluorescent profile of a family of self-calibrating dyes that provide ratiometric measurements of fluid viscosity. The design is based on covalently linking a primary fluorophore (reference) that displays a viscosity-independent fluorescence emission with a secondary fluorophore (sensor) that exhibits a viscosity-sensitive fluorescence emission. Characterization of fluorescent properties was made with separate excitation of the units and through Resonance Energy Transfer from the reference to the sensor dye. The chemical structures of both fluorophores and the linker length have been evaluated in order to optimize the overall brightness and sensitivity of the viscosity measurements. We also present an application of such ratiometric dyes for the detection of membrane viscosity changes in a liposome model.

BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES

The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

ortho-Formylation of oxygenated phenols

Oxygenated phenols are mono-formylated using a mixture of paraformaldehyde, MgCl2, and Et3N in THF. In all cases but one, only one regioisomer of the salicylaldehyde is obtained in good to high yield.

Synthesis of aspirochlorine precursors

Synthesis of key precursors of aspirochlorine (1) and related compounds has been achieved in 5 steps from 1, 4-diacetyl-2,5-piperazinedione (2). MCPBA mediated oxidative cyclization of 1-acetyl-3-salicylidene-2,5-piperazinedione (4) yielded a spiro 3 H-be