89939-35-5

Upstream product

• 99502-89-3 Chlorameisensaeure-N-hydroxy-norborn-5-en-2,3-dicarboximidester 
• 936-02-7 2-Hydroxybenzoylhydrazine 
• 503-38-8 trichloromethyl chloroformate 
• 29638-33-3 5-(2-hydroxyphenyl)-2-mercapto-1,3,4-oxadiazole 
• 541-41-3 chloroformic acid ethyl ester 
• 70203-02-0 N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide 
• 119-36-8 methyl salicylate 

Downstream Products

• 92244-86-5 2-acetoxy-5-(2-acetoxy-phenyl)-[1,3,4]oxadiazole 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Some Heterocyclic Compounds from Salicylic Acid Hydrazide

Different heterocyclic compounds were prepared starting from 2-hydroxy benzohydrazide; for example, cyclization of hydrazide hydrazone 3 derived from 2-hydroxybenzohydrazide 2 with acetic anhydride or concentrated sulfuric acid gave 1,3,4-oxadiazole derivatives 4–5. On the other hand, direct cyclization of 2-hydroxy benzohydrazide 2 with one carbon cyclizing agent gave a new derivative of 1,3,4-oxadiazole 7, 8, 9, 10, 11. Heating of hydrazide hydrazone 3 with thioglycolic acid in pyridine gave thiazolidinone 12. When 2-hydroxy benzohydrazide 2 reacted with aliphatic carboxylic acids such as formic acid or acetic acid, it gave the corresponding N-formyl or N-acetyl derivatives 6. Subsequent cyclization of 6 using phosphorous pentasulphide in pyridine gave 1,3,4-thiadiazoles 13. Cyclization of 2-hydroxy benzohydrazide with ethyl acetoacetate gives pyrazolone derivative 14. Finally, when an ethanolic solution of acid hydrazide 2 was treated with ammonium thiocyanate in 35% HCl, it gave the thiosemicarbazide 15. Subsequent treatment of 15 with concentrated sulfuric acid or 10% sodium hydroxide gave 5-amino-1,3,4-thiadiazole 16 and 1,2,4-triazole 17, respectively. The structures of all newly isolated compounds were confirmed using1H NMR, IR spectra, and elemental analyses. The antimicrobial activities for all isolated compounds were examined against different microorganisms.

Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4- oxadiazole-2(3H)-ones in water

It has been developed for the synthesis of substituted-1,3,4-oxadiazole- 2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields.

Some 1-Aroyl-4,4-dialkylsemicarbazides and Their Cyclization to Afford 5-Aryl-1,3,4-oxadiazol-2(3H)-ones

Some 1-aroyl-4,4-dialkylsemicarbazides have been prepared by reacting aroyl-hydrazides with dimethyl- or diethyl-carbamoyl chloride.In boiling DMF they lose dimethylamine or diethylamine to give 5-aryl-1,3,4-oxadiazol-2(3H)-ones. - Keywords: 1-Aroyl-4,4-d

Herbicidal sulfonamides

This invention relates to herbicidal benzene sulfonamides containing a five or six membered heterocyclic ring consisting of 2-3 heteroatoms and 1-2 carbonyl groups as a substituent on benzene.