89943-28-2Relevant articles and documents
Solvent- and Catalyst-Free Aza-Michael Addition of Imidazoles and Related Heterocycles
Gobec, Florian,Kodolitsch, Katharina,Slugovc, Christian
, (2020/05/18)
This work demonstrates the scope and limitations of the aza-Michael addition of imidazoles and related heterocycles with electron deficient olefins under solvent- and catalyst-free conditions. The reaction proceeds at 80 °C within hours towards completion as long as the azole derivative is sufficiently soluble in the Michael acceptor, which has been used in small excess. Workup only comprises evaporation of surplus Michael-acceptor, and no additional solvents are necessary for purifying the products.
Vilsmeier-Haack formylation of 1H-pyrazoles
Badalyan,Akopyan,Attaryan,Asratyan
, p. 793 - 795 (2014/06/09)
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Aza-Michael addition of aliphatic or aromatic amines to α,β-unsaturated compounds catalyzed by a DBU-derived ionic liquid under solvent-free conditions
Ying, An-Guo,Liu, Luo,Wu, Guo-Feng,Chen, Gang,Chen, Xin-Zhi,Ye, Wei-Dong
experimental part, p. 1653 - 1657 (2009/06/28)
A task-specific ionic liquid, 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate has been successfully used as a catalyst for aza-conjugate addition of aliphatic or aromatic amines to various electron deficient alkenes under solvent-free conditions and at room temperature. The catalyst can be reused for six times without noticeable loss of activity.