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N-hydroxy-N-glucuronosyl-2-aminofluorene is a chemical compound formed during the metabolism of the carcinogen 2-aminofluorene in the body. It plays a crucial role in the activation of 2-aminofluorene, leading to DNA damage and potentially carcinogenic effects. Known as a potent mutagen, it has been implicated in the development of bladder cancer. Understanding its metabolism and effects is vital for developing strategies for cancer prevention and treatment.

89947-76-2

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89947-76-2 Usage

Uses

Used in Cancer Research:
N-hydroxy-N-glucuronosyl-2-aminofluorene is utilized as a research compound to study the mechanisms of carcinogenesis and mutagenicity. Its role in the activation of 2-aminofluorene aids in understanding the pathways leading to DNA damage and cancer development.
Used in Drug Development:
N-hydroxy-N-glucuronosyl-2-aminofluorene serves as a target for the development of drugs aimed at preventing or mitigating the effects of 2-aminofluorene metabolism. By inhibiting the formation or activity of N-hydroxy-N-glucuronosyl-2-aminofluorene, potential chemopreventive agents can be designed to reduce the risk of carcinogenic effects.
Used in Toxicology Studies:
N-hydroxy-N-glucuronosyl-2-aminofluorene is employed in toxicological research to evaluate the safety and potential health risks associated with exposure to 2-aminofluorene and related compounds. This helps in establishing guidelines and regulations for exposure limits and environmental safety.
Used in Environmental Monitoring:
As a biomarker for exposure to carcinogenic compounds, N-hydroxy-N-glucuronosyl-2-aminofluorene can be used in environmental monitoring programs to assess contamination levels and implement corrective measures to protect public health.

Check Digit Verification of cas no

The CAS Registry Mumber 89947-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,9,4 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 89947-76:
(7*8)+(6*9)+(5*9)+(4*4)+(3*7)+(2*7)+(1*6)=212
212 % 10 = 2
So 89947-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H19NO7/c21-14-15(22)17(19(24)25)27-18(16(14)23)20(26)11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)13/h1-6,8,14-18,21-23,26H,7H2,(H,24,25)/t14-,15-,16+,17-,18+/m0/s1

89947-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-[9H-fluoren-2-yl(hydroxy)amino]-3,4,5-trihydroxyoxane-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89947-76-2 SDS

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