899699-66-2Relevant academic research and scientific papers
Potent small molecule inhibitors of spleen tyrosine kinase (Syk)
Lai, Justine Y. Q.,Cox, Paul J.,Patel, Rajesh,Sadiq, Shazia,Aldous, David J.,Thurairatnam, Sukanthini,Smith, Keith,Wheeler, Darren,Jagpal, Savita,Parveen, Sofia,Fenton, Gary,Harrison, Trevor K. P.,McCarthy, Clive,Bamborough, Paul
, p. 3111 - 3114 (2003)
A series of oxindoles demonstrating inhibition of the phosphorylation of biotinylated substrates of Syk and IgE/FcεRI triggered basophil cell degranulation has been identified. A study of the SAR around sulfonamide 31 (IC50=5 nM, EC50=1400 nM) is discussed. The modest cellular activity representative of the sulfonamide series was overcome when the Polar Surface Area was lowered to 2, leading to the identification of amide 32 (IC50=145 nM, EC50=100 nM).
DESIGN, SYNTHESIS OF NOVEL RNA-DEPENDENT RNA POLYMERASE OXYINDOLE INHIBITORS
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, (2022/01/05)
The present invention relates to new compounds represented by formulas I, II and III, including any conformational isomer form, salts and solvates, for the inhibition of RNA polymerase RNA-dependent on DENV. The present invention also relates to a method
