89977-13-9Relevant academic research and scientific papers
Preparation of saccharincarboxylic acids and -carboxylic acid esters
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, (2008/06/13)
Saccharincarboxylic acids and -carboxylic acid esters of the formula I STR1 where the substituents have the following meanings: L and M are hydrogen, alkyl, alkoxy, alkylthio, chlorine, cyano, alkylsulfonyl, nitro or trifluoromethyl; Z is hydrogen, alkyl, cycloalkyl, alkyl, aryl or aralkyl; R is H or C1 -C6 -alkyl, are prepared by reacting corresponding bromo- or iodo-substituted saccharin derivatives of the formula II STR2 where L, M and Z have the abovementioned meanings, or if Z≠H, compounds of the formula III STR3 in the presence of a palladium, nickel, cobalt or rhodium transition metal catalyst and of a base with carbon monoxide and water or a C1 -C6 -alcohol under elevated pressure.
Saccharin derivatives
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, (2008/06/13)
Saccharin derivatives of the formula I STR1 where the substituents have the following meanings: L and M are hydrogen, C1 -C4 -alkyl, C1 -C4 -alkoxy, C1 -C4 -alkylthio, chlorine, cyano, meth
5-hydroxypyrazol-4-ylcarbonyl-substituted saccharin derivatives
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, (2008/06/13)
5-Hydroxypyrazol-4-ylcarbonyl-substituted saccharin derivatives of the formula I STR1 where the substituents have the following meanings: L and M are hydrogen, C1 -C4 -alkyl, C1 -C4 -alkoxy, C1 -Csub
Saccharin derivatives
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, (2008/06/13)
Saccharin derivatives of the formula I STR1 where the substituents have the following meanings: L and M are hydrogen, C1 -C4 -alkyl, C1 -C4 -alkoxy, C1 -C4 -alkylthio, chlorine, cyano, methylsulfonyl, nitro or trifluoromethyl; Z is hydrogen, C1 -C4 -alkyl, C3 -C8 -cycloalkyl, C3 -C6 -alkenyl, C3 -C5 -alkynyl, C1 -C4 -acyl, benzyl or phenyl, the phenyl rings in each case being unsubstituted or substituted by halogen or C1 -C4 -alkyl; Q is a radical T-J, where T is a carbonyl radical CO or the radical --CHY, J is a 4-linked isoxazole ring of the formula II STR2 where R1 is hydrogen or C1 -C4 -alkyl and R2 is C1 -C4 -alkyl, cyclopropyl, 1-methylcyclopropyl or 1-methylthiocyclopropyl; Y is an OH group, a hydroxyl group which may be acylated by C2 -C4 -acyl or a chlorine atom; and agriculturally customary salts of the compounds I are described.
HUMAN LEUKOCYTE ELASTASE (HLE) INHIBITORS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
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, (2008/06/13)
Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have the structural formula (I) STR1 wherein R 1 through R 9, m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and
