89977-30-0Relevant articles and documents
Continuous-Flow Process for Selective Mononitration of 1-Methyl-4-(methylsulfonyl)benzene
Yu, Zhiqun,Zhou, Pengcheng,Liu, Jiming,Wang, Wenzuo,Yu, Chuanming,Su, Weike
, p. 199 - 203 (2016)
An expeditious process for selective nitration of 1-methyl-4-(methylsulfonyl)benzene in a continuous-flow reactor in 98% yield is described. The continuous-flow mononitration ran well in adiabatic condition with 80 wt% sulfuric acid, and residence time was reduced to 5 s. The short residence time can significantly reduce byproducts. Dinitration was also studied for optimization of the mononitration. The spent acid could be reused for several times after concentration in a vacuum.