89978-46-1

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Bromo-2-iodo-4,5-dimethoxybenzene is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of organic compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 1-Bromo-2-iodo-4,5-dimethoxybenzene is utilized as a key intermediate for the production of other organic compounds. Its versatile chemical properties enable it to be a crucial component in the synthesis of various molecules.
Used in Research Applications:
1-Bromo-2-iodo-4,5-dimethoxybenzene is also employed in research settings, where its unique structure and properties are studied to gain insights into chemical reactions and the development of new synthetic pathways.
Used in Industrial Applications:
In the industrial sector, 1-Bromo-2-iodo-4,5-dimethoxybenzene is used in the production of various organic compounds for a range of applications, including the manufacturing of specialty chemicals and materials. Its versatility and reactivity make it a valuable asset in the chemical industry.

InChI:InChI=1/C8H8BrIO2/c1-11-7-3-5(9)6(10)4-8(7)12-2/h3-4H,1-2H3

Upstream product

• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 120093-94-9 [1-(3',4'-dimethoxyphenyl)vinyl]trimethylsilane 
• 17423-55-1 3,4-dimethoxy-1,1'-biphenyl 
• 951215-29-5 N-[4-(2-ethynyl-4,5-dimethoxyphenyl)but-3-ynyl]benzenamine 
• 1150112-10-9 1-bromo-3,4-dimethoxy-6-(2-trimethylsilylethynyl)benzene 
• 1260216-14-5 7-(2',3',4,5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-15-6 (R)-7-(2',3',4,5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-16-7 7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-17-8 (R)-7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-18-9 7-(2',4,5-trimethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-19-0 7-(3',4,5-trimethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-20-3 7-(4,4',5-trimethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-23-6 7-(4,5-dimethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 6879-02-3 (+)-tylocrebrine 
• 30061-35-9 Tylocrebrin 

Relevant academic research and scientific papers

A Fourfold Benzodehydroannuleno-Fused Porphyrazine

Four benzodehydroannulene subunits were implemented on a dibenzoquinoxalinopoprhyrazine core using efficient palladium-mediated alkyne coupling and oxidative acetylene coupling on phenanthrene dione precursors. Despite the significant amount of strain in system, as evidenced by X-ray analysis of an immediate precursor, porphyrazine assembly leads to an extended model for N-doped graphyne with photosensitizing properties.

Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C

A concise, efficient and modular approach to the tylophora alkaloids is described, a family of potent cytotoxic agents that are equally effective against drug sensitive and multidrug resistant cancer cell lines. The advantages of the chosen route are illustrated by the total syntheses of the phenanthroquinolizidine cryptopleurine (1) and the phenanthroindolizidines (-)-antofine (2), (-)-tylophorine (3), and their only recently isolated congener (-)-ficuseptine C (4). The key steps consist in a Suzuki cross-coupling between a (commercial) boronic acid and a simple aryl-l,2-dihalide followed by elaboration of the resulting products into the corresponding 2-alkynyl-biphenyl derivatives 27, 33, 41 and 46. The latter undergo PtCl2-catalyzed cycloisomerizations with formation of the functionalized phenanthrenes 28, 34, 42 and 47, which were transformed into the targeted alkaloids by a deprotection/Pictet-Spengler annulation tandem. Due to the flexibility and robust character of this approach, it might enable a systematic exploration of the pharmacological profile of this promising class of bioactive natural products.

Efficient halogenation of aromatic systems using N-halosuccinimides in ionic liquids

A simple, rapid and highly regioselective green protocol has been developed for the halogenation of aromatic systems with N-halosuccinimides using room temperature ionic liquids (ILs) as novel and recyclable reaction media to produce the corresponding halogenated aromatic compounds in high to quantitative yields. N-Halosuccinimides show enhanced reactivity in ionic liquids thereby reducing the reaction times dramatically and improving the yields substantially.

1,5-EPOXY-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINS AND USE IN TREATMENT OF ULCERS

The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.