899798-79-9

Upstream product

• 872369-17-0 (2R,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentanal 
• 899798-76-6 (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanoic acid 
• 899798-78-8 (3S,4R,5R,6S)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-octan-2-one 
• 109262-86-4 (3S,4S)-1-(benzyloxy)-4-methylhex-5-en-3-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 899798-75-5 (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2,4-dimethyl-heptan-1-one 
• 899798-74-4 (2S,3R,4S,5S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-hydroxy-2,4-dimethyl-heptan-1-one 
• 899798-73-3 (2R,3S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-pentan-1-one 
• 899798-77-7 (2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanoic acid methoxy-methyl-amide 
• 899798-72-2 (2R,3S)-5-Benzyloxy-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-hydroxy-2-methyl-pentan-1-one 

Downstream Products

• 899798-80-2 [(3S,4R,5S,6R,7S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-4,6-dimethyl-octyloxymethyl]-benzene 
• 899798-87-9 5-[(3S,4R,5S,6R,7S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-4,6-dimethyl-octylsulfanyl]-1-phenyl-1H-tetrazole 
• 899798-66-4 5-[(3S,4R,5S,6R,7S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-4,6-dimethyl-octane-1-sulfonyl]-1-phenyl-1H-tetrazole 
• 899798-88-0 5-[(E)-(3S,4S,9S,10R,11S,12R,13S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-13-methoxy-3-methoxymethoxy-4,10,12-trimethyl-tetradec-6-enylsulfanyl]-1-phenyl-1H-tetrazole 
• 899798-64-2 5-[(E)-(3S,4S,9S,10R,11S,12R,13S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-13-methoxy-3-methoxymethoxy-4,10,12-trimethyl-tetradec-6-ene-1-sulfonyl]-1-phenyl-1H-tetrazole 
• 899798-82-4 C₄₈H₈₆O₆Si₃ 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship study of FD-891: Importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells

Unified synthesis of FD-891 analogs and their structure-activity relationship are described. By using stereoselective allylation/crotylation and Evans aldol chemistry, six side-chain fragments having different length and terminus were synthesized. These f

Stereoselective synthesis of the cytotoxic macrolide FD-891

A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were first stereoselectively constructed using mainly asymmetric aldol and allylation reactions. The complete framework was then assembled using two Jul