89980-69-8

Basic information

• Product Name: 3,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE
• Synonyms: 3,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE;3,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;3,4-dimethoxyphenylmagnesium bromide solution;3,4-Dimethoxyphenylmagnesium bromide solution 0.5 in THF;3,4-DiMethoxyphenylMagnesiuM broMide, 0.5M in THF;3,4-Dimethoxyphenylmagnesium bromide 0.5M solution in THF;3,4-DiMethoxyphenylMagnesiuM broMide, 0.5M solution in THF, J&KSeal;3,4-Dimethoxyphenylmagnesium bromide solution 0.5 M in THF
• CAS NO: 89980-69-8
• Molecular Formula: C₈H₉BrMgO₂
• Molecular Weight: 241.36
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 89980-69-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: 1 °F
• Appearance: /
• Density: 0.960 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Water Solubility: Reacts with water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 3,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE(89980-69-8)
• EPA Substance Registry System: 3,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE(89980-69-8)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-19-34-37-36/37-40
• Safety Statements: 16-26-36/37/39-45-36/37-43-8
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• HazardClass: 3
• Hazardous Substances Data: 89980-69-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9O2.BrH.Mg/c1-9-7-5-3-4-6-8(7)10-2;;/h3,5-6H,1-2H3;1H;/q;;+1/p-1/rC8H9BrMgO2/c1-11-7-4-3-6(10-9)5-8(7)12-2/h3-5H,1-2H3

Upstream product

• 2859-78-1 4-Bromoveratrole 

Downstream Products

• 776-99-8 3,4-dimethoxyphenylacetone 
• 79445-45-7 3-(3,4-Dimethoxyphenyl)pyridine 
• 107971-40-4 2-(3,4-Dimethoxy-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 91-16-7 1,2-dimethoxybenzene 
• 152867-94-2 <5-(3',4'-Dimethoxyphenyl)pentyl>-(tetrahydro-2''H-pyran-2''-yl)-ether 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 100986-54-7 Acetic acid (1S,5R,6S,8S)-6-(3,4-dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl ester 
• 132283-76-2 (1S,1'R)-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-2-(2-hydroxy-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 
• 85010-20-4 2-<2-(3,4-dimethoxyphenyl)-3,4-dimethoxyphenyl>-4,4-dimethyl-2-oxazoline 
• 100986-51-4 (1S,5R,6S,8S)-6-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octan-6-ol 
• 79821-77-5 (S)-2-((benzenesulfonyl)amino)-1-(3,4-dimethoxyphenyl)-1-propanone 
• 126325-73-3 2,4-dihydroxy-4-(3,4-dimethoxyphenyl)cyclohexanone 1-(2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 30405-75-5 4-isopropenyl-1,2-dimethoxybenzene 
• 322640-11-9 (2S,5R)-2-[1-(3,4-Dimethoxy-phenyl)-1-methyl-ethyl]-5-methyl-cyclohexanone 

Relevant articles and documents

A total synthesis of (+)-brazilin

Described herein is a concise total synthesis of (+)-brazilin from readily available 4-bromo-1,2-dimethoxybenzene. In this synthetic route, a Sharpless asymmetric dihydroxylation was employed to introduce the chiral hydroxyl group, and trifluoroacetic acid (TFA) catalyzed one-pot intramolecular tandem Prins/Friedel-Crafts reaction was also involved as the key transformation in the construction of the hybrid chromane and indane framework.

2-(PIPERIDIN-4-YL) -4, 5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS

The compounds of a certain formula (1), in which R1, R2, R3 and R9 have the meanings as given in the description, are novel effective PDE4 inhibitors.