899809-10-0Relevant articles and documents
Novel Intermediates, Process for Their Preparation and Process for the Preparation of Coq10 Employing the Said Novel Intermediates
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Page/Page column 18, (2008/12/08)
The present invention relates to an improved process for the preparation of Coenzyme Q. Coenzyme Q10 or CoQ10 has the chemical name 2-[(all-trans)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone and has the formula I. The invention also provides new intermediates useful for the preparation of CoQ10 and processes for their preparation.
NOVEL INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND PROCESS FOR THE PREPARATION OF COQ10 EMPLOYING THE SAID NOVEL INTERMEDIATES
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Page/Page column 8; 16-17, (2008/06/13)
The present invention relates to an improved process for the preparation of Coenzyme Q. Coenzyme QlO or CoQlO has the chemical name 2- [(all -trans)- 3, 7,l l,15,19,23,27,31,35,39-decamethyl-2, 6, 10, 14, 18, 22, 26, 30, 34, 38 - tetracontadecaenyl]-5-6-dimethoxy -3- methyl -1,4-benzoquinone and has the formula 1. The invention also provides new intermediates useful for the preparation of CoQlO and processes for their preparation.
Friedel-Crafts allylation of 2-(benzyloxy)-3,4,5-trimethoxytoluene catalysed by a metal trifluoromethanesulfonic salt: Synthesis of coenzyme Q10
Zheng, Yun-Feng,Lin, Jing-Du,Li, Cheng-Ping,Li, Jing-Hua
, p. 686 - 688 (2008/09/21)
In the presence of a catalytic amount of scandium triflate, 2-benzyloxy-3,4,5-trimethoxytoluene reacted with allylic derivatives 4, giving the key intermediate 3 (R = benzyl) which was used for preparing coenzyme Q10, in moderate to high yields.
PROCESS FOR THE PREPARATION OF UBIHYDROQUINONES AND UBIQUINONES
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Page/Page column 9; 12, (2008/06/13)
A process for the preparation of ubihydroquinones and ubiquinones by condensation of a prenol or isoprenol with a hydroquinone or derivative thereof in the presence of 0.005 - 1.0 mol% of a catalyst which is a Broensted-acid, a Lewis-acid from the group consisting of a derivative of Bi or In or an element of group 3 of the periodic table of the elements, a heteropolyacid, an NH- or a CH-acidic compound, and optionally oxidizing the ubihydroquinone obtained.