899809-77-9Relevant academic research and scientific papers
Thrombin Receptor Antagonists Based On The Modified Tricyclic Unit Of Himbacine
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Page/Page column 29, (2008/06/13)
Multiple stereoisomers of the heterocyclic-substituted tricyclics of the formula: or a pharmaceutically acceptable salt, solvate, or ester of said compound wherein R and the stereochemistry are illustrated in the structural formulas herein are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
PREPARATION OF CHIRAL PROPARGYLIC ALCOHOL AND ESTER INTERMEDIATES OF HIMBACINE ANALOGS
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Page/Page column 30; 32, (2008/06/13)
This application discloses a novel process for the conversion of a series of racemic propargylic alcohols to corresponding (R)-enantiomers. The application also discloses the enantio-selective esterification of a propargylic alcohol from its racemate to p
