89983-80-2Relevant academic research and scientific papers
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: Structure-activity relationships of novel thiohydrazone analogues
Kalinowski, Danuta S.,Sharpe, Philip C.,Bernhardt, Paul V.,Richardson, Des R.
, p. 6212 - 6225 (2007)
Di-2-pyridylketone isonicotinoyl hydrazone Fe chelators utilize the N,N,O-donor set and have moderate anti-proliferative effects. Their closely related N,N,S-thiosemicarbazone analogues, namely, the di-2-pyridylketone thiosemicarbazones, exhibit markedly
RING-RING AND RING-CHAIN TAUTOMERISM IN THE THIOBENZOYLHYDRAZONES OF ALIPHATIC β-DICARBONYL COMPOUNDS
Zelenin, K. N.,Alekseev, V. V.,Khrustalev, V. A.,Yakimovich, S. I.,Nikolaev, V. N.,Koshmina, N. V.
, p. 162 - 167 (2007/10/02)
The 5-hydroxy-4,5-dihydropyrazole-2,3-dihydro-1,3,4-thiadiazole ring-ring tautomeric equilibrium in solutions was investigated by NMR spectroscopy for the products from the condensation of thiobenzohydrazide with aliphatic β-dioxo compounds.In polar media (DMSO) ring-chain tautomeric equilibrium involving the enehydrazine or hydrazone tautomers is also observed in individual cases. 1-Phenylthioacetyl-3,5-dimethyl-5-hydroxy-4,5-dihydropyrazole is formed during the condensation of acetylacetone with phenylthioacetylhydrazine, and 1-thiobenzoyl-3-acetylacetamidrazone was obtained from thiobenzoylhydrazide and monothiodiacetamide.
