89989-01-5

Usage

Uses

Used in Pharmaceutical Research:
1-(4-chloro-2-Methoxyphenyl)piperazine is used as a research chemical for the development of new medications, primarily targeting central nervous system disorders. Its application in this field is due to its potential to interact with neurological receptors and pathways, offering a promising avenue for the treatment of various conditions.
Used in Treatment of Central Nervous System Disorders:
In the medical industry, 1-(4-chloro-2-Methoxyphenyl)piperazine is used as a compound for exploring potential treatments for central nervous system disorders. The reason for its application in this area is its ability to modulate neurotransmitter activity and potentially alleviate symptoms associated with these disorders.
Used in Psychoactive Research:
1-(4-chloro-2-Methoxyphenyl)piperazine is also used as a research chemical in the study of psychoactive effects. Its application in this field is driven by its known psychoactive properties, which can provide insights into the development of new therapies for mental health conditions and the understanding of cognitive and emotional processes.

Upstream product

• 93-50-5 4-chloro-o-anisidine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 

Relevant academic research and scientific papers

Heteroaromatic acetamide derivative, preparation and applications thereof

The present invention provides a heteroaromatic acetamide derivative, a preparation and applications thereof, wherein the derivative comprises a pharmaceutically acceptable salt and/or a solvate thereof. According to the present invention, the experiment results prove that the heteroaromatic acetamide derivative can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit orreduce the activity of TRPA1, and can be used for treating diseases mediated by TRPA1; and the inhibitor of the present invention further comprises a pharmaceutical composition of the compound, and amethods for preparing the compounds. The derivative has a general formula defined in the specification.

5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS

The present invention discloses 5-[3-[piperazin-l-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives according to Formula (I), wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS 4 and 5 for the prophylaxis or treatment of inflammatory diseases or diseases involving degradation of cartilage or disruption of cartilage homeostasis, such as e.g. osteoarthritis.

PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS

Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.

1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.