89991-29-7Relevant academic research and scientific papers
Automated multistep continuous flow synthesis of 2-(1H-indol-3-yl)thiazole derivatives
Pagano, Nicholas,Heil, Marintha L.,Cosford, Nicholas D. P.
experimental part, p. 2537 - 2546 (2012/09/05)
The multistep continuous flow assembly of 2-(1H-indol-3-yl)thiazoles using a Syrris AFRICA synthesis station is reported. Sequential Hantzsch thiazole synthesis, deketalization, and Fischer indole synthesis provides rapid and efficient access to highly functionalized, pharmacologically significant 2-(1H-indol-3-yl)thiazoles. These complex drug-like small molecules are generated in reaction times of less than 15 minutes and in high yields (38-82% over three chemical steps without isolation of intermediates). Georg Thieme Verlag Stuttgart · New York.
HETEROCYCLES IN ORGANIC SYNTHESIS. PART VI - A FACILE SYNTHESIS OF 1-(4-ARYL-2-THIAZOLYL)-2-PROPANONES
Singh, Harjit,Aggarwal, Sunil K.,Malhotra, Nageshwar
, p. 353 - 354 (2007/10/02)
Reactions of ω-(6-methyl-4-pyrimidinylthio)acetophenones (1) with aq.HCl/HClO4 or POCl3 followed by hydrolysis provide 1-(4-aryl-2-thiazolyl)-2-propanones (3).
EXTRUSION REACTIONS-VII. FORMATION OF 2,5-DIARYL-1,4-DITHIINS AND 2-ACETONYL THIAZOLES
Singh, Harjit,Aggarwal, Sunil K.,Malhotra, Nageshwar
, p. 4941 - 4946 (2007/10/02)
ω-(2,6-Dimethyl-4-pyrimidinylthio-(4), 2-methyl-4-quinazolinylthio-(9), and 4-oxo-2-quinazolinylthio)-(10) acetophenones with hydrochloric or perchloric acid provide 2,5-diaryl-1,4-dithiins (7) whereas ω-(6-methyl-4-pyrimidinylthio)acetophenones (11) with aq HCl/HClO4 or POCl3 followed by hydrolysis provide 1-(4-aryl-2-thiazolyl)-2-propanones (12).Likewise, 2-(6-methyl-4-pyrimidinylthio)cyclohexanone (13) give the thiazole derivative (14).
