9000-81-1 Usage
Uses
Different sources of media describe the Uses of 9000-81-1 differently. You can refer to the following data:
1. Acetylcholinesterase (AChE) from Sigma has been used in the structure-activity study of phosphoramido acid esters as inhibitors of AChE.
2. Acetylcholinesterase from Electrophorus electricus (electric eel) has been used:in acetylcholinesterase activity assayto study its effects on Xenopus embryonic hippocampal cellsto study the effect of acetylcholine inhibitors on development and plasticity
Definition
Any substance that inhibits or inactivates acetylcholinesterase, thereby preventing the hydrolysis of acetylcholine. Their action leads to an accumulation of endogenous acetylcholine with a resultant hyperactivity of cholinergic neurons, which can prove lethal.
General Description
Predominantly exists as a tetrameric glycoprotein composed of disulfide-linked homodimers with a monomer MW of ~80 kDa.
Hazard
Tremors; convulsions; respiratory failure; death.
Biochem/physiol Actions
Acetylcholinesterase (AChE) is regarded as a biomarker in neurotoxicity. It is a modulator of nitric oxide signal transduction pathway and marker of membrane integrity and aging. The levels of erythrocyte (RBC) AChE are affected on pesticide exposure and in hemolytic anemia. RBC AChE is a marker in Hirschsprung′s disease and inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 9000-81-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 9000-81:
(6*9)+(5*0)+(4*0)+(3*0)+(2*8)+(1*1)=71
71 % 10 = 1
So 9000-81-1 is a valid CAS Registry Number.